CAJ | 학술논문

宫颈上皮内瘤样病变（CIN）是一种癌前病变，可分为CINⅠ、CINⅡ和CINⅢ。国内对CINⅡ及以上者主要采取手术治疗，但术后仍有一定的复发率。影响复发的因素较多，包括切缘阳性、宫颈管诊刮阳性、机体免疫力降低、高龄等。人乳头瘤病毒（HPV）与CIN复发的关系尚不十分明确，但基本能够确定HPV持续感染可增加CIN复发率，且HPV亚型和HPV负荷量在其中起重要作用。综述HPV对CIN复发的影响。
궁경상피내류양병변（CIN）시일충암전병변，가분위CINⅠ、CINⅡ화CINⅢ。국내대CINⅡ급이상자주요채취수술치료，단술후잉유일정적복발솔。영향복발적인소교다，포괄절연양성、궁경관진괄양성、궤체면역력강저、고령등。인유두류병독（HPV）여CIN복발적관계상불십분명학，단기본능구학정HPV지속감염가증가CIN복발솔，차HPV아형화HPV부하량재기중기중요작용。종술HPV대CIN복발적영향。
Cervical intraepithelial neoplasia (CIN) is a precancerous change,which can be divided into grade one,grade two and grade three. The disease should be taken to surgery when the pathologic change is more serious than CINⅠ. But there is still some postoperative recurrence rate. There are plenty of factors affecting the recurrence rate ,including positive margins, positive endocervical curettage,reduced immunity,senium and so on. Until now,the relationship between HPV and the recurrence rate is not clear,but it′s confirmed that the persistent infection with HPV must increase the recurrence rate. Furthermore,the load of HPV and subtypes of HPV have played an important role in increasing the rate of CIN recurrence. This paper described the influence of HPV on CIN recurrence.