CAJ | 학술논문

二甲双胍作为一线降糖药物，在糖尿病治疗领域发挥重要作用。代谢综合征（MS）是多种代谢物异常集结的病理状态，与其有关的远期不良结局日益受到关注。研究发现，MS各环节与子宫内膜样腺癌发病机制关系密切，两者可能存在共同的病理生理基础———胰岛素抵抗。二甲双胍具有抑制胰岛素抵抗、调节细胞因子水平及独特的抗肿瘤干细胞功能，可能发挥重要的负性调节作用，并可能成为MS人群预防及治疗子宫内膜样腺癌的新型药物。
이갑쌍고작위일선강당약물，재당뇨병치료영역발휘중요작용。대사종합정（MS）시다충대사물이상집결적병리상태，여기유관적원기불량결국일익수도관주。연구발현，MS각배절여자궁내막양선암발병궤제관계밀절，량자가능존재공동적병리생리기출———이도소저항。이갑쌍고구유억제이도소저항、조절세포인자수평급독특적항종류간세포공능，가능발휘중요적부성조절작용，병가능성위MS인군예방급치료자궁내막양선암적신형약물。
Metformin as the first-line drugs, play an important role in the treatment of diabetes. Metabolic syndrome (MS) is a pathological condition of abnormal aggregation of multiple metabolite resulting. The long-term adverse outcomes were payed more and more attention by people. The study found, MS is recognized risk factor of endometrial adenocarcinoma, there may be a common pathophysiological basis of insulin resistance. Metformin reduces insulin resistance, regulates the level of cytokines and exerts anti-tumor stem cell function, it is a potent inhibitor of metabolic syndrome and endometrial adenocarcinoma.