CAJ | 학술논문

经典雌激素受体（ER）及其变异体、雌激素膜受体（mER）参与介导雌激素不同生物效应。多项研究表明，雌激素与子宫内膜癌的发生、发展过程密切相关，目前普遍接受的子宫内膜癌形成的原因是子宫内膜受到过度雌激素刺激并缺乏孕激素拮抗。雌激素发挥其效应主要依赖ER，研究ER对了解子宫内膜癌发生、发展的可能机制起到了重要作用，并为子宫内膜癌的诊断及治疗提供了新的思路。综述ER及其变异体的结构、功能及其与子宫内膜癌的关系，为深入研究提供思路。
경전자격소수체（ER）급기변이체、자격소막수체（mER）삼여개도자격소불동생물효응。다항연구표명，자격소여자궁내막암적발생、발전과정밀절상관，목전보편접수적자궁내막암형성적원인시자궁내막수도과도자격소자격병결핍잉격소길항。자격소발휘기효응주요의뢰ER，연구ER대료해자궁내막암발생、발전적가능궤제기도료중요작용，병위자궁내막암적진단급치료제공료신적사로。종술ER급기변이체적결구、공능급기여자궁내막암적관계，위심입연구제공사로。
The classical estrogen receptor (ER) and its variants,membrane estrogen receptor (mER) involved in mediating different signaling effects of estrogen. Studies have shown estrogen is closely related to the occurrence and development process of endometrial cancer ,while excessive estrogen stimulation and lack of progesterone antagonist is widely accepted as the main cause of endometrial cancer and the function of estrogen is mediated by estrogen receptor. Learning the possible mechanisms of the occurrence and development of endometrial cancer and finding new ways for its diagnosis and treatment through estrogen receptor also showing great significance. This paper reviews the structure and function of estrogen receptor,and analyses its relationship with endometrial cancer.