CAJ | 학술논문

肿瘤间质包括间质肌纤维母细胞、上皮细胞、粒细胞等。大量研究表明，肿瘤间质可产生诸如蛋白酶、生长因子、免疫调节因子等大量分子，通过影响肿瘤微环境中细胞内外双向的信号交换网络，参与肿瘤细胞的增殖分化、细胞凋亡、黏附及迁移等过程，与多种肿瘤的发生发展密切相关。近年研究表明，肿瘤间质在卵巢癌的发生发展、侵袭转移等过程中扮演重要角色，其与卵巢癌临床病理特征及预后有关，已成为当前卵巢癌生物学干预治疗的热门靶点。
종류간질포괄간질기섬유모세포、상피세포、립세포등。대량연구표명，종류간질가산생제여단백매、생장인자、면역조절인자등대량분자，통과영향종류미배경중세포내외쌍향적신호교환망락，삼여종류세포적증식분화、세포조망、점부급천이등과정，여다충종류적발생발전밀절상관。근년연구표명，종류간질재란소암적발생발전、침습전이등과정중분연중요각색，기여란소암림상병리특정급예후유관，이성위당전란소암생물학간예치료적열문파점。
The tumor stroma consists of stromal myofibroblasts,endothelial cells,and leukocytes. A large amount of evidence indicates that tumor stroma could produce proteases,growth factors,immune response-modulating proteins and so on and respond to stimuli initiated in the tumor cells to establish a bi-directional communication network in the microenvironment to promote tumor cell proliferation,apoptosis,cell adhesion and tumor invasion. They are closely related to tumor growth and progression. Recently,studies indicate that tumor stroma played an important role in the development and invasion and metastasis of ovarian cancer,and is related to clinicopathological characteristics and prognosis of ovarian cancer. Tumor stroma has been regarded as a hot target for biological intervention in treatment of ovarian cancer.