中国药物应用与监测
中國藥物應用與鑑測
중국약물응용여감측
CHINESE JOURNAL OF DRUG APPLICATION AND MONITORING
2014年
6期
372-375
,共4页
苗秋丽%闫荟羽%张四喜%宋燕青
苗鞦麗%閆薈羽%張四喜%宋燕青
묘추려%염회우%장사희%송연청
药品不良反应%报告%分析
藥品不良反應%報告%分析
약품불량반응%보고%분석
Adverse drug reaction%Report%Analysis
目的：了解我院药品不良反应（ADR）发生的一般规律及特点，为临床合理用药提供参考。方法：采用回顾性分析方法，对我院2012年1月–2013年12月上报的953例ADR报告从ADR发生的年龄与性别分布、给药途径、药品种类、累及的系统/器官及临床表现、ADR报告类型及ADR转归等方面进行统计分析。结果：953例ADR报告中，男性458例（48.06%），女性495例（51.94%）；ADR在各年龄段均有分布，51~60岁者ADR发生率最高，有192例，占20.15%；引起ADR药品以抗感染药物居多，且主要为头孢菌素类，其次为抗肿瘤药物；引发ADR的给药途径以静脉滴注为主，占71.14%；ADR最常累及系统/器官为消化系统，占40.20%；一般ADR占98.22%，大多好转或治愈；新的ADR 2例；严重ADR 15例，其中11例留有后遗症，拉莫三嗪片引起死亡1例。结论：临床应高度重视ADR监测和报告工作，以减少或避免ADR重复发生，促进合理用药。
目的：瞭解我院藥品不良反應（ADR）髮生的一般規律及特點，為臨床閤理用藥提供參攷。方法：採用迴顧性分析方法，對我院2012年1月–2013年12月上報的953例ADR報告從ADR髮生的年齡與性彆分佈、給藥途徑、藥品種類、纍及的繫統/器官及臨床錶現、ADR報告類型及ADR轉歸等方麵進行統計分析。結果：953例ADR報告中，男性458例（48.06%），女性495例（51.94%）；ADR在各年齡段均有分佈，51~60歲者ADR髮生率最高，有192例，佔20.15%；引起ADR藥品以抗感染藥物居多，且主要為頭孢菌素類，其次為抗腫瘤藥物；引髮ADR的給藥途徑以靜脈滴註為主，佔71.14%；ADR最常纍及繫統/器官為消化繫統，佔40.20%；一般ADR佔98.22%，大多好轉或治愈；新的ADR 2例；嚴重ADR 15例，其中11例留有後遺癥，拉莫三嗪片引起死亡1例。結論：臨床應高度重視ADR鑑測和報告工作，以減少或避免ADR重複髮生，促進閤理用藥。
목적：료해아원약품불량반응（ADR）발생적일반규률급특점，위림상합리용약제공삼고。방법：채용회고성분석방법，대아원2012년1월–2013년12월상보적953례ADR보고종ADR발생적년령여성별분포、급약도경、약품충류、루급적계통/기관급림상표현、ADR보고류형급ADR전귀등방면진행통계분석。결과：953례ADR보고중，남성458례（48.06%），녀성495례（51.94%）；ADR재각년령단균유분포，51~60세자ADR발생솔최고，유192례，점20.15%；인기ADR약품이항감염약물거다，차주요위두포균소류，기차위항종류약물；인발ADR적급약도경이정맥적주위주，점71.14%；ADR최상루급계통/기관위소화계통，점40.20%；일반ADR점98.22%，대다호전혹치유；신적ADR 2례；엄중ADR 15례，기중11례류유후유증，랍막삼진편인기사망1례。결론：림상응고도중시ADR감측화보고공작，이감소혹피면ADR중복발생，촉진합리용약。
[ABSTRACT]Objective:To investigate the feature and regularity of adverse drug reactions (ADRs) occurred in our hospital and provide reference for rational medication in clinic.Methods:A total of 953 ADR reports were collected and retrospectively analyzed from January 2012 to December 2013. The reports were classiifed and analyzed statistically in respect of the age and gender distribution of the patients, route of administration, the category of drugs, organs or systems involved in ADRs and main clinical manifestations, types and outcomes of ADRs, etc.Results: Among the 953 ADR cases, 458 cases (48.06%) were male and 495 cases (51.94%) were female. Totally 192 patients (20.15%) were 51 – 60 years old. Most of the ADRs were induced by anti-infective drugs (mainly in cephalosporins), and follwed by antitumor drugs; the main administration route was intravenous drip, accounting for 71.14%; most of ADRs commonly involved in digestive system, accounting for 40.20%. Moderate ADRs accounted for 98.22%, most of them were improved or cured. There were 2 new ADRs and 15 serious ADRs, including 11 cases of sequela, 1 case of lamotrigine-related death.Conclusion: Great importance should be attached to ADR monitoring and reporting, to reduce or avoid the occurrence of ADR, and promote rational drug use.
