CAJ | 학술논문

环境改变和污染所引起下一代的变化是深刻的，其中胎儿则是最敏感的人群之一。持续性有机污染物（PO Ps ）是环境中很重要的一类化学污染物，随着气候变化和经济快速发展使得其暴露水平和模式也发生改变[1]。虽然许多PO Ps在多年前已被淘汰，但由于它们具有持久性、亲脂性、生物累积性、半挥发性和高毒性，在环境中仍有残留。目前国内外动物实验和人群流行病学调查研究显示，孕期暴露PO Ps可能会对妊娠结局及儿童生长发育产生不良影响。其中包括低出生体质量、早产、出生缺陷、儿童神经系统和生殖系统发育不良等，本文以人群流行病调查资料为基础对孕期暴露PO Ps对下一代产生的上述影响进行阐述。
배경개변화오염소인기하일대적변화시심각적，기중태인칙시최민감적인군지일。지속성유궤오염물（PO Ps ）시배경중흔중요적일류화학오염물，수착기후변화화경제쾌속발전사득기폭로수평화모식야발생개변[1]。수연허다PO Ps재다년전이피도태，단유우타문구유지구성、친지성、생물루적성、반휘발성화고독성，재배경중잉유잔류。목전국내외동물실험화인군류행병학조사연구현시，잉기폭로PO Ps가능회대임신결국급인동생장발육산생불량영향。기중포괄저출생체질량、조산、출생결함、인동신경계통화생식계통발육불량등，본문이인군류행병조사자료위기출대잉기폭로PO Ps대하일대산생적상술영향진행천술。
Environmental changes and pollution have profound effects on the fetus .Persistent organic pollutants (POPs) are a very important category of chemical pollutants in the environment .With the rapid deterioration of the climate ,the exposure levels and patterns of POPs have changed .Although many POPs were eliminated years ago , due to their persistence ,lipophilicity ,bioaccumulation ,semi volatility and high toxicity ,there are still residual POPs in the environment .Current animal experiments and epidemiological researches home and abroad have showed that prenatal exposure to POPs may have adverse effect on pregnancy outcome and infant growth and development , including low birth weight ,premature birth ,birth defects ,dysplasia of nervous and reproductive systems .This paper reviewed the effects of POPs exposure on fetus based on population‐based epidemiological survey data .