CAJ | 학술논문

目的：观察Fah－／－小鼠对NTBC的药物依赖性，更详尽的掌握该模型的生物学特征，使该模型得以更有效的利用。方法 Fah－／－小鼠NTBC停药后，观察小鼠体重变化、生存状态、生存时间，定期取样记录血清学和肝脏病理学变化。结果 NTBC停药后，Fah－／－小鼠体重进行性下降，活力降低，5～7周死亡，期间伴随着ALT、AST等血清指标的升高及肝细胞严重变性及大量坏死。结论 Fah－／－小鼠需终身服用NTBC，依赖性强，停药会出现严重肝损伤，表明该模型是研究酪氨酸血症Ⅰ型和其他肝损伤的理想模型。
목적：관찰Fah－／－소서대NTBC적약물의뢰성，경상진적장악해모형적생물학특정，사해모형득이경유효적이용。방법 Fah－／－소서NTBC정약후，관찰소서체중변화、생존상태、생존시간，정기취양기록혈청학화간장병이학변화。결과 NTBC정약후，Fah－／－소서체중진행성하강，활력강저，5～7주사망，기간반수착ALT、AST등혈청지표적승고급간세포엄중변성급대량배사。결론 Fah－／－소서수종신복용NTBC，의뢰성강，정약회출현엄중간손상，표명해모형시연구락안산혈증Ⅰ형화기타간손상적이상모형。
Objective To observe the NTBC dependence of Fah-knockout mice and study the biological characteristics in order to use the model more effectively.Methods Examine the progressive changes in body weight, survival time, liver pathology and serological markers after the NTBC withdrawal.Results After removing of NTBC, Fah-knockout mice lost their body weight gradually, and finally died in 5 to 7 weeks, along with increased serum ALT, AST levels and deformation of the hepatocytes.Conclusions Fah-knockout mice have a strong drug dependence of NTBC and could be the ideal model to hereditary tyrosinemia type I and other liver injury.