中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2014年
12期
1130-1134
,共5页
罗祎明%徐捷慧%易湛苗%翟所迪
囉祎明%徐捷慧%易湛苗%翟所迪
라의명%서첩혜%역담묘%적소적
奥卡西平%卡马西平%三叉神经痛%荟萃分析
奧卡西平%卡馬西平%三扠神經痛%薈萃分析
오잡서평%잡마서평%삼차신경통%회췌분석
oxcarbazepine%carbamazepine%primary trigeminal neuralgia%Meta-analysis
目的：评价奥卡西平和卡马西平治疗原发性三叉神经痛的疗效和安全性。方法计算机检索Cochrane library、PubMed、Medline、中国生物医学文献数据库、中国知网和万方等数据库，结合手工检索，收集比较奥卡西平与卡马西平治疗原发性三叉神经痛的随机对照研究，对其进行风险偏倚评估，并交叉核对，用RevMan 5.2软件进行数据分析。结果共纳入18项研究，共1465例患者。奥卡西平组总有效率优于卡马西平组[RR＝1.09，95％CI（1.02，1.16），P＜0.05]；治疗前和治疗后第2，4周视觉模拟评分（VAS）改善2组差异无统计学意义；治疗前与治疗后8周VAS评分的改善奥卡西平组优于卡马西平组[ MD＝－3.20，95％CI （－5.17，－1.22），P＝0.001]。奥卡西平组不良反应发生率低于卡马西平组[RR＝0.50，95％CI（0.39，0.63），P＜0.001]。发表偏倚对研究结果影响小。结论奥卡西平治疗原发性三叉神经痛在疗效不劣于卡马西平，且耐受性优于卡马西平。
目的：評價奧卡西平和卡馬西平治療原髮性三扠神經痛的療效和安全性。方法計算機檢索Cochrane library、PubMed、Medline、中國生物醫學文獻數據庫、中國知網和萬方等數據庫，結閤手工檢索，收集比較奧卡西平與卡馬西平治療原髮性三扠神經痛的隨機對照研究，對其進行風險偏倚評估，併交扠覈對，用RevMan 5.2軟件進行數據分析。結果共納入18項研究，共1465例患者。奧卡西平組總有效率優于卡馬西平組[RR＝1.09，95％CI（1.02，1.16），P＜0.05]；治療前和治療後第2，4週視覺模擬評分（VAS）改善2組差異無統計學意義；治療前與治療後8週VAS評分的改善奧卡西平組優于卡馬西平組[ MD＝－3.20，95％CI （－5.17，－1.22），P＝0.001]。奧卡西平組不良反應髮生率低于卡馬西平組[RR＝0.50，95％CI（0.39，0.63），P＜0.001]。髮錶偏倚對研究結果影響小。結論奧卡西平治療原髮性三扠神經痛在療效不劣于卡馬西平，且耐受性優于卡馬西平。
목적：평개오잡서평화잡마서평치료원발성삼차신경통적료효화안전성。방법계산궤검색Cochrane library、PubMed、Medline、중국생물의학문헌수거고、중국지망화만방등수거고，결합수공검색，수집비교오잡서평여잡마서평치료원발성삼차신경통적수궤대조연구，대기진행풍험편의평고，병교차핵대，용RevMan 5.2연건진행수거분석。결과공납입18항연구，공1465례환자。오잡서평조총유효솔우우잡마서평조[RR＝1.09，95％CI（1.02，1.16），P＜0.05]；치료전화치료후제2，4주시각모의평분（VAS）개선2조차이무통계학의의；치료전여치료후8주VAS평분적개선오잡서평조우우잡마서평조[ MD＝－3.20，95％CI （－5.17，－1.22），P＝0.001]。오잡서평조불량반응발생솔저우잡마서평조[RR＝0.50，95％CI（0.39，0.63），P＜0.001]。발표편의대연구결과영향소。결론오잡서평치료원발성삼차신경통재료효불렬우잡마서평，차내수성우우잡마서평。
Objective To compare the efficacy and safety of oxcarba-zepine and carbamazepine for primary trigeminal neuralgia management.Methods Cochrane library, PubMed, Medline, CBMdisc, CNKI and Wanfang Data were searched to collect the randomized controlled studies that compared the efficacy and safety of oxcarbazepine and carbamazepine in treating primary trigeminal neuralgia.Reference list of each primary study was hand -searched.Two reviewers independently screened the literatures, extracted data, assessed risks of bias and then did cross -checking.RevMan 5.2 software was used for Meta -analysis.Results Eighteen studies ( 1465 participants ) were included.Results of Meta -analysis showed that oxcarbazepine was more effective than carbama-zepine [RR=1.09,95%CI (1.02,1.16), P<0.05].Comparisons of VAS before and after 2 and 4 weeks of treatment were not significantly different between two groups , while comparisons of VAS before and after the 8weeks of treatment favored oxcarbazepine.Oxcarbazepine was asso-ciated with a lower incidence of adverse drug reaction than carbamazepine [RR=0.50,95%CI(0.39,0.63),P<0.001].The influence of repor-ting bias is small.Conclusion Compared with carbamazepine , oxcarba-zepine is not inferior in efficacy but superior in safety in treating primary trigeminal neuralgia.
