CAJ | 학술논문

目的：观察头孢哌酮／舒巴坦与美罗培南联合时对35株临床分离的美罗培南耐药的鲍曼不动杆菌的体外抗菌作用。方法采用微量肉汤稀释法及联合药敏棋盘法，对35株鲍曼不动杆菌进行头孢哌酮／舒巴坦和美罗培南的体外联合药物敏感性测定，通过计算部分抑菌指数（ FIC）来判断头孢哌酮／舒巴坦与美罗培南的联合效应。结果头孢哌酮／舒巴坦与美罗培南联用对35株美罗培南耐药的鲍曼不动杆菌的最低抑菌浓度（MIC）较单用均明显下降（P＜0.01）；用联合药敏棋盘法检测协同作用为54.3％（19／35），部分协同作用为34.3％（12／35），相加作用为5.7％（2／35），无关作用为5.7％（2／35），无拮抗作用。结论头孢哌酮／舒巴坦联合美罗培南对于美罗培南耐药的鲍曼不动杆菌主要表现为协同和部分协同作用。
목적：관찰두포고동／서파탄여미라배남연합시대35주림상분리적미라배남내약적포만불동간균적체외항균작용。방법채용미량육탕희석법급연합약민기반법，대35주포만불동간균진행두포고동／서파탄화미라배남적체외연합약물민감성측정，통과계산부분억균지수（ FIC）래판단두포고동／서파탄여미라배남적연합효응。결과두포고동／서파탄여미라배남련용대35주미라배남내약적포만불동간균적최저억균농도（MIC）교단용균명현하강（P＜0.01）；용연합약민기반법검측협동작용위54.3％（19／35），부분협동작용위34.3％（12／35），상가작용위5.7％（2／35），무관작용위5.7％（2／35），무길항작용。결론두포고동／서파탄연합미라배남대우미라배남내약적포만불동간균주요표현위협동화부분협동작용。
Objective To evaluate the synergy effect of cefperazone -sulbactam and meropenem combination against 35 meropenem-resistant Acinetobacter baumannii isolated from clinical specimens in vitro.Methods The synergy effect of cefperazone -sulbactam and meropenem combination was evaluated through microdilution checkerboard method a-gainst 35 meropenem resistant A.baumannii were isolated from inpa-tients.The inhibitory concentration against antimicrobials was detected . The synergy effect of combination was assessed by fractional inhibitory concentration index ( FIC).Results The minimal inhibitory concentra-tion ( MIC) of 35 meropenem-resistant Acinetobacter baumannii against cefperazone-sulbactam and meropenem combined were decreased com-pared with single -use ( P<0.01 ).The checkerboard method with the combination of cefperazone -sulbactam and meropenem demonstrated 54.3%(19/35)synergism, 34.3%(12/35)partial synergism, 5.7%(2/35)additive, 5.7%(2/35)indifference, no antagonism in our study.Con-clusion Cefperazone -sulbactam and meropenem combination show syn-ergism or partial synergism against most Acinetobacter baumannii isolates.