CAJ | 학술논문

研究表明，糖尿病患者体内多种蛋白质可与血糖发生缓慢、稳定、不可逆的生化效应形成可测定的相应的糖基化终末产物，如糖化血红蛋白（HbA1c）及糖化白蛋白（GA）。HbA1c、GA水平与血糖及糖尿病并发症密切相关，且其检测结果受血红蛋白（Hb）及白蛋白等因素的影响。高原地区高海拔、低氧、寒冷等独特的地理、气候条件使得人体内多器官、系统的病理及生理有别于平原地区，这些变化使糖尿病患者的诊治较平原地区更为复杂、特殊。本文就HbA1c、GA及其在高原地区的相关研究做一综述。
연구표명，당뇨병환자체내다충단백질가여혈당발생완만、은정、불가역적생화효응형성가측정적상응적당기화종말산물，여당화혈홍단백（HbA1c）급당화백단백（GA）。HbA1c、GA수평여혈당급당뇨병병발증밀절상관，차기검측결과수혈홍단백（Hb）급백단백등인소적영향。고원지구고해발、저양、한랭등독특적지리、기후조건사득인체내다기관、계통적병리급생리유별우평원지구，저사변화사당뇨병환자적진치교평원지구경위복잡、특수。본문취HbA1c、GA급기재고원지구적상관연구주일종술。
Evidence shows that various proteins in diabetic patients are glycosylated in a slow, stable, and irreversible biochemical reaction, and then form some determinable glycosylation end products, such as glycosylated hemoglobin A (HbA1c) and glycosylated albumin (GA). Serum levels of HbA1c and GA are closely associated with blood glucose and diabetes complications, and their test results are affected by some factors, such as hemoglobin (Hb) and albumin. Hypoxia, cold and other unique geographical and climatic conditions at the high altitude make the multi-organic and multi-systematic pathological and physiological status of human body different from those living at the plains, and these differences make the diagnosis and treatment of diabetes patients who live at the high altitude more complicated and distinctive than people at the plain area. This review mainly introduced HbA1c, GA and some related investigations at the high altitude.