世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
12期
1662-1665
,共4页
张欣%吴敏%阎秀菊%马博
張訢%吳敏%閻秀菊%馬博
장흔%오민%염수국%마박
辛夷挥发油%纳米%温敏凝胶%体外释药%体内释药
辛夷揮髮油%納米%溫敏凝膠%體外釋藥%體內釋藥
신이휘발유%납미%온민응효%체외석약%체내석약
Magnolia volatile oil,Nano%Temperature-sensitive gel%In vitro release%In vivo release
目的：研究温敏型辛夷纳米凝胶在体内和体外的释药规律。方法：体内释药规律研究采用在体大鼠鼻腔灌洗法，体外释药规律研究采用 Franz 扩散池法，利用 HPLC 法进行测定。结果：体外释药实验表明温敏型辛夷纳米凝胶12 h 累积释放率为14％；采用动力学模型处理表明，温敏型辛夷纳米凝胶体内释药模式符合一级动力学过程，具有缓释效应。结论：温敏型辛夷纳米凝胶具备良好的缓释性能。
目的：研究溫敏型辛夷納米凝膠在體內和體外的釋藥規律。方法：體內釋藥規律研究採用在體大鼠鼻腔灌洗法，體外釋藥規律研究採用 Franz 擴散池法，利用 HPLC 法進行測定。結果：體外釋藥實驗錶明溫敏型辛夷納米凝膠12 h 纍積釋放率為14％；採用動力學模型處理錶明，溫敏型辛夷納米凝膠體內釋藥模式符閤一級動力學過程，具有緩釋效應。結論：溫敏型辛夷納米凝膠具備良好的緩釋性能。
목적：연구온민형신이납미응효재체내화체외적석약규률。방법：체내석약규률연구채용재체대서비강관세법，체외석약규률연구채용 Franz 확산지법，이용 HPLC 법진행측정。결과：체외석약실험표명온민형신이납미응효12 h 루적석방솔위14％；채용동역학모형처리표명，온민형신이납미응효체내석약모식부합일급동역학과정，구유완석효응。결론：온민형신이납미응효구비량호적완석성능。
Objective:To study the drug release of temperature-sensitive nanogels of Magnolia in vitro and in vivo.Methods:We inves-tigated the process of in vitro drug release of temperature-sensitive nanogel of Magnolia with Franz diffusion cell.The regulation of nasal absorption of temperature-sensitive nanogel of Magnolia was investigated by the rat in situ nasal deposit method.The method of HPLC was conducted.Results:The study on drug release in vitro showed that the cumulative release rate in12 hours was 14%.The treatment of dynamic model showedthat the absorption process of this preparation fitted the first-order dynamics process,with slow-release effect. Conclusion:Temperature-sensitive nanogels of Magnolia has satisfactory slow-release effect.
