CAJ | 학술논문

目的：初步探索醒脾解郁方对抑郁模型大鼠的抗抑郁行为和血清激素、神经递质变化的影响。方法：本实验将 SD 大鼠随机分为4组：正常组、模型对照组、舍曲林对照组、中药（石菖蒲、西洋参、郁金、熟地黄）组，采用21 d 慢性不可预见性温和应激建立抑郁大鼠模型，以糖水偏爱和旷野试验移动距离评价各组大鼠抑郁行为，用 ELISA 法测定大鼠血清5-羟色胺、皮质酮含量，并比较醒脾解郁方对其影响的作用。结果：21 d 慢性应激建立大鼠抑郁模型后，与正常组比较，模型组体重降低明显（P ＜0.01），糖水偏爱率、旷场试验移动距离显著下降（P ＜0.01），同时模型组血清皮质酮含量显著增加（P ＜0.01）、5-HT 明显降低（P ＜0.01）；与模型组比较，中药组和舍曲林组均能显著改善大鼠抑郁行为（P ＜0.05），并且醒脾解郁方和舍曲林均对抑郁大鼠血清皮质酮、5-HT 均有显著逆转作用（P ＜0.05）。结论：醒脾解郁方具有抗抑郁作用，并与舍曲林效果相当，并能逆转抑郁模型大鼠血清皮质酮、5-HT 的作用，这可能是其改善抑郁的作用机制。
목적：초보탐색성비해욱방대억욱모형대서적항억욱행위화혈청격소、신경체질변화적영향。방법：본실험장 SD 대서수궤분위4조：정상조、모형대조조、사곡림대조조、중약（석창포、서양삼、욱금、숙지황）조，채용21 d 만성불가예견성온화응격건립억욱대서모형，이당수편애화광야시험이동거리평개각조대서억욱행위，용 ELISA 법측정대서혈청5-간색알、피질동함량，병비교성비해욱방대기영향적작용。결과：21 d 만성응격건립대서억욱모형후，여정상조비교，모형조체중강저명현（P ＜0.01），당수편애솔、광장시험이동거리현저하강（P ＜0.01），동시모형조혈청피질동함량현저증가（P ＜0.01）、5-HT 명현강저（P ＜0.01）；여모형조비교，중약조화사곡림조균능현저개선대서억욱행위（P ＜0.05），병차성비해욱방화사곡림균대억욱대서혈청피질동、5-HT 균유현저역전작용（P ＜0.05）。결론：성비해욱방구유항억욱작용，병여사곡림효과상당，병능역전억욱모형대서혈청피질동、5-HT 적작용，저가능시기개선억욱적작용궤제。
Objective:To preliminarily explore the effect of Xingpijieyu decoction on depressive behavior and serum 5-HT and corticos-terone on depression model rats.Methods:SD rats were randomly divided into 4 groups:normal group,model control group,sertraline control group,and traditional Chinese medicine (stone calamus,American ginseng,radix curcumae,cultivated land)group.21 days chro-nic unpredictable mild stress was adopted to establish the rat model of depression,using sucrose preference and open-field test to evaluate depression of rats,and compare the change of 5-HT and corticosterone form every groups of rats by ELISA.Results:After 21 days of chro-nic stress depression rats model made,compared with normal group,weight,preference for sugar water rate and open-field total distance of the model group were significantly decreased (P <0.01),and serum corticosterone increased significantly (P <0.01),serum 5-HT sig-nificantly decreased (P <0.01);Compared with model group,sertraline group and Chinese medicine group both could improve depres-sive behavior (P <0.05),and reverse serum 5-HT and corticosterone significantly (P <0.05).Conclusion:Xingpijieyu Decoction can improve chronic unpredictable stress depression rats model depression function,which is the same as sertraline controls.Xingpijieyu de-coction also could reverse erum 5-HT and corticosterone from depression rats,which might be related to its improvement of depression.