世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
12期
1572-1574,1580
,共4页
黄倩兰%阳仁达%周灿%谢力
黃倩蘭%暘仁達%週燦%謝力
황천란%양인체%주찬%사력
恒河猴%皮层切除%面口合谷收%脑功能重组
恆河猴%皮層切除%麵口閤穀收%腦功能重組
항하후%피층절제%면구합곡수%뇌공능중조
Rhesus monkeys%Sensory cortex resection%Neurons discharge%Brain function reorganization%Diseases of the face and mouth apply Hegu
目的：研究切除恒河猴感觉皮层手区对恒河猴感觉皮层脑功能重组的影响，探讨病理状况下大脑皮层对手区与面区感觉功能的调控作用是否发生代偿，揭示“面口合谷收”可能的生物学机制。方法：手术切除恒河猴感觉皮层手区，通过微电极细胞外记录寻找恒河猴感觉皮层 SⅠ神经元的放电，观察其外周感受野的变化。结果：恒河猴感觉皮层手区切除后3个月、6个月、9个月，手区神经元的外周感受野消失，随着切除时间的延长，在已切除的手区可逐步记录到数量不等对面部和前臂刺激起反应的神经元，对面部刺激起反应的区域明显大于对前臂刺激起反应的区域。结论：1）感觉皮层手区功能的丧失导致与其毗邻的面区、前臂之间发生功能重组，面区和前臂区均逐步向手区扩展。2）功能重组似乎有一定的趋向性，即面区和手区之间的功能重组强于前臂区和手区。3）病理状况下大脑皮层手区和面区的功能重组可能是“面口合谷收”重要的生物学机制。
目的：研究切除恆河猴感覺皮層手區對恆河猴感覺皮層腦功能重組的影響，探討病理狀況下大腦皮層對手區與麵區感覺功能的調控作用是否髮生代償，揭示“麵口閤穀收”可能的生物學機製。方法：手術切除恆河猴感覺皮層手區，通過微電極細胞外記錄尋找恆河猴感覺皮層 SⅠ神經元的放電，觀察其外週感受野的變化。結果：恆河猴感覺皮層手區切除後3箇月、6箇月、9箇月，手區神經元的外週感受野消失，隨著切除時間的延長，在已切除的手區可逐步記錄到數量不等對麵部和前臂刺激起反應的神經元，對麵部刺激起反應的區域明顯大于對前臂刺激起反應的區域。結論：1）感覺皮層手區功能的喪失導緻與其毗鄰的麵區、前臂之間髮生功能重組，麵區和前臂區均逐步嚮手區擴展。2）功能重組似乎有一定的趨嚮性，即麵區和手區之間的功能重組彊于前臂區和手區。3）病理狀況下大腦皮層手區和麵區的功能重組可能是“麵口閤穀收”重要的生物學機製。
목적：연구절제항하후감각피층수구대항하후감각피층뇌공능중조적영향，탐토병리상황하대뇌피층대수구여면구감각공능적조공작용시부발생대상，게시“면구합곡수”가능적생물학궤제。방법：수술절제항하후감각피층수구，통과미전겁세포외기록심조항하후감각피층 SⅠ신경원적방전，관찰기외주감수야적변화。결과：항하후감각피층수구절제후3개월、6개월、9개월，수구신경원적외주감수야소실，수착절제시간적연장，재이절제적수구가축보기록도수량불등대면부화전비자격기반응적신경원，대면부자격기반응적구역명현대우대전비자격기반응적구역。결론：1）감각피층수구공능적상실도치여기비린적면구、전비지간발생공능중조，면구화전비구균축보향수구확전。2）공능중조사호유일정적추향성，즉면구화수구지간적공능중조강우전비구화수구。3）병리상황하대뇌피층수구화면구적공능중조가능시“면구합곡수”중요적생물학궤제。
Objective:To study the effect of removal of the hand area in rhesus monkeyssensory cortex on the reorganization of brain function,and explore in pathological situations whether the cerebral cortex would make a compensation for regulating the sensory function of face,mouth and the hand area,so as to reveal possible biological mechanisms of the “diseases of the face and mouth apply Hegu”the-ory.Methods:To obtain experimental models by Surgically removing the rhesusthe hand area of sensory cortex,search for neuron dis-charge of rhesus monkeyssensory cortex through the extracellular recording by microelectrode,and observe changes in neurons periphery reception field within the area of the hand and face in sensory cortex.Results:Three months after resection of rhesus monkeyshand area in sensory cortex,those originally reacted to facial stimulation now react to both the stimulations from face and hands.Conclusion:1)The lose of the hand area in sensory cortex lead to functional reorganization both in the face and forearm area.At the same time,the face and forearm area are gradually expand to the hand area.2)Functional reorganization seems to have a certain tendency,that is to say the functional reorganization between face area and hand area are stronger then the functional reorganization between forearm area and hand area.3)Under pathological condition,the functional reorganization of hand area and face area in cerebral cortex maybe the biological mechanism of the “diseases of the face and mouth apply Hegu”.
