CAJ | 학술논문

目的探讨OPRM1基因多态性（rs1799971）对浙南地区女性妇科手术患者舒芬太尼自控镇痛效果的影响。方法收集浙南地区妇科手术患者200例，抽取外周血，采用直接测序法，分析患者OPRM1基因多态性（rs1799971），比较不同基因组患者之间舒芬太尼的累积量，记录镇痛起效时间、持续时间、VAS分值及不良反应。结果 AA型127例，AG型62例，GG型11例，O-PRM1基因多态性（rs1799971）基因突变频率为36.50%，各基因组术后2、6、12h舒芬太尼累积量比较，AA组累积量最少，AG组及GG组均较AA组增高，差异有统计学意义（P＜0.05），术后24、48h，GG组较AA组及AG组增高，差异有统计学意义（P＜0.05）。各基因型组间不良反应发生率的差异均无统计学意义（均P＞0.05）。结论在浙南地区女性人群中，OPRM1基因多态性（rs1799971）对舒芬太尼镇痛效果有显著影响。
목적탐토OPRM1기인다태성（rs1799971）대절남지구녀성부과수술환자서분태니자공진통효과적영향。방법수집절남지구부과수술환자200례，추취외주혈，채용직접측서법，분석환자OPRM1기인다태성（rs1799971），비교불동기인조환자지간서분태니적루적량，기록진통기효시간、지속시간、VAS분치급불량반응。결과 AA형127례，AG형62례，GG형11례，O-PRM1기인다태성（rs1799971）기인돌변빈솔위36.50%，각기인조술후2、6、12h서분태니루적량비교，AA조루적량최소，AG조급GG조균교AA조증고，차이유통계학의의（P＜0.05），술후24、48h，GG조교AA조급AG조증고，차이유통계학의의（P＜0.05）。각기인형조간불량반응발생솔적차이균무통계학의의（균P＞0.05）。결론재절남지구녀성인군중，OPRM1기인다태성（rs1799971）대서분태니진통효과유현저영향。
Objective To investigate the association between OPRM1 gene polymorphisms and efficacy of sufen-tanil in postoperative patient- control ed analgesia . Methods Two hundred patients undergoing hystermyoma received post-operative patient- control ed analgesia (PCA) with sufentanil from January 2010 to May 2012. Peripheral blood samples were col ected for DNA extraction. OPRM1 gene(rs1799971) polymorphisms were detected. The sufentanil consumption, the release time on analgesia, analgesic duration, VAS, and adverse reaction were documented and compared among different genotype groups. Results Genotyping analysis revealed that the genotype distribution of polymorphisms in OPRM1 gene was AA in 127 cases, AG in 62 cases, and GG in 11 cases. The frequency of OPRM1 mutation was 36.5%. The sufentanil consumption at 2h, 6h and 12h after surgery and VAS at 24h and 48h after surgery in GG group were higher than those in AG and AA groups (P<0.05). Conclusion The results indicate that OPRM1 gene polymorphism has the significant impact on analgesic efficacy of sufentanil.