现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
24期
3690-3691,3694
,共3页
利钠肽,脑%慢性病%心肌梗死%早期诊断%治疗应用
利鈉肽,腦%慢性病%心肌梗死%早期診斷%治療應用
리납태,뇌%만성병%심기경사%조기진단%치료응용
Natriuretic peptide,brain%Chronic disease%Myocardial infarction%Early diagnosis%Therapeutic uses
目的：探讨血浆N末端脑钠肽前体（NT_proBNP）水平在陈旧性心肌梗死检测中的临床应用价值。方法对2012年4月至2014年4月来该院诊治的80例陈旧性心肌梗死患者的入院资料进行分析，采用胶体金法试剂盒48 h内对患者NT_proBNP 水平进行测定，根据患者血浆NT_proBNP 水平进行分组，≥300 pg/mL 为观察组，<300 pg/mL 为对照组，各40例。两组患者均行常规检查，比较两组患者NT_proBNP平均水平、住院时间、预后等相关指标。结果观察组血浆NT_proBNP平均水平[（698.20±384.50）pg/mL]高于对照组（48.45±25.26）pg/mL，住院时间[（18.27±6.73）d]长于对照组[（15.52±5.81）d]，差异均有统计学意义（P<0.05）；观察组不良反应发生率为37.50％（15/40），高于对照组的17.50％（7/40），差异有统计学意义（P<0.05）；NT_proBNP平均水平小于1500 ng/mL的患者的心血管疾病发生率为10.87％（5/46），NT_proBNP平均水平为1500~3000 ng/mL的患者的心血管疾病发生率为47.37％（9/19），NT_proBNP平均水平大于3000 ng/mL的患者的心血管疾病发生率为73.33％（11/13）。结论 NT_proBNP的血浆水平是陈旧性心肌梗死患者预后的重要因子，可作为陈旧性心肌梗死的判断因素。
目的：探討血漿N末耑腦鈉肽前體（NT_proBNP）水平在陳舊性心肌梗死檢測中的臨床應用價值。方法對2012年4月至2014年4月來該院診治的80例陳舊性心肌梗死患者的入院資料進行分析，採用膠體金法試劑盒48 h內對患者NT_proBNP 水平進行測定，根據患者血漿NT_proBNP 水平進行分組，≥300 pg/mL 為觀察組，<300 pg/mL 為對照組，各40例。兩組患者均行常規檢查，比較兩組患者NT_proBNP平均水平、住院時間、預後等相關指標。結果觀察組血漿NT_proBNP平均水平[（698.20±384.50）pg/mL]高于對照組（48.45±25.26）pg/mL，住院時間[（18.27±6.73）d]長于對照組[（15.52±5.81）d]，差異均有統計學意義（P<0.05）；觀察組不良反應髮生率為37.50％（15/40），高于對照組的17.50％（7/40），差異有統計學意義（P<0.05）；NT_proBNP平均水平小于1500 ng/mL的患者的心血管疾病髮生率為10.87％（5/46），NT_proBNP平均水平為1500~3000 ng/mL的患者的心血管疾病髮生率為47.37％（9/19），NT_proBNP平均水平大于3000 ng/mL的患者的心血管疾病髮生率為73.33％（11/13）。結論 NT_proBNP的血漿水平是陳舊性心肌梗死患者預後的重要因子，可作為陳舊性心肌梗死的判斷因素。
목적：탐토혈장N말단뇌납태전체（NT_proBNP）수평재진구성심기경사검측중적림상응용개치。방법대2012년4월지2014년4월래해원진치적80례진구성심기경사환자적입원자료진행분석，채용효체금법시제합48 h내대환자NT_proBNP 수평진행측정，근거환자혈장NT_proBNP 수평진행분조，≥300 pg/mL 위관찰조，<300 pg/mL 위대조조，각40례。량조환자균행상규검사，비교량조환자NT_proBNP평균수평、주원시간、예후등상관지표。결과관찰조혈장NT_proBNP평균수평[（698.20±384.50）pg/mL]고우대조조（48.45±25.26）pg/mL，주원시간[（18.27±6.73）d]장우대조조[（15.52±5.81）d]，차이균유통계학의의（P<0.05）；관찰조불량반응발생솔위37.50％（15/40），고우대조조적17.50％（7/40），차이유통계학의의（P<0.05）；NT_proBNP평균수평소우1500 ng/mL적환자적심혈관질병발생솔위10.87％（5/46），NT_proBNP평균수평위1500~3000 ng/mL적환자적심혈관질병발생솔위47.37％（9/19），NT_proBNP평균수평대우3000 ng/mL적환자적심혈관질병발생솔위73.33％（11/13）。결론 NT_proBNP적혈장수평시진구성심기경사환자예후적중요인자，가작위진구성심기경사적판단인소。
Objective To investigate levels of plasma NT_proBNP in patients with old myocardial infarction in the clini_cal application value of detection. Methods The database of 80 patients with old myocardial infarction received by this hospital from April 2013 to April 2014 were analyzed. and divided into the observation group and the control group ,40 in each group ac_cording to their levels of plasma NT_proBNP detected by colloidal gold kit. The both groups were conducted routine examination , whose plasma NT_proBNP concentrations were measured by enzyme linked immunosorbent assay. The mean NT_proBNP levels, hospitalization time and related indicators of prognosis were compared and analyzed. Results The plasma NT_proBNP levelsin the observation group[(698.20±384.50)pg/mL] was higher than that of the control group[(48.45±25.26)pg/mL],and hospitalization time[(12.8±6.7)d] was longer than that of the control group[(8.1±6.7)d] with statistically significant differences(P<0.05);the incidence of adverse reactions of the observation group[37.50%(15/40)] was lower than that of the control group[17.50%(7/40)], and the difference had statistically significance (P<0.05). The occurrence rates of cardiovascular disease in patients with the aver_age level of NT_proBNP<1 500 ng/mL,1 500~3 000 ng/mL and>3 000 ng/mL were 10.87%(5/46),47.37%(9/19) and 73.33%(11/13) respectively. Conclusion The plasma concentration of NT_proBNP is an important factor for the prognosis of patients with old myocardial infarction ,which was deemed as one of the judgment factors.
