CAJ | 학술논문

由于关节软骨主要是由软骨细胞和周围的外基质组成的无血管组织，损伤后自我修复能力比较弱，利用基因转染技术治疗软骨损伤性疾病是基因工程研究的重点，而软骨细胞和骨髓间充质干细胞（BMSCs）是基因转染技术中最主要和最常用的种子细胞，与之相关的基因转染的研究也是目前研究的热点。本文拟就与软骨细胞和BMSCs相关的基因转染方面（包括病毒载体、单基因转染和多基因转染）取得的成果和最新研究进展作一综述。
유우관절연골주요시유연골세포화주위적외기질조성적무혈관조직，손상후자아수복능력비교약，이용기인전염기술치료연골손상성질병시기인공정연구적중점，이연골세포화골수간충질간세포（BMSCs）시기인전염기술중최주요화최상용적충자세포，여지상관적기인전염적연구야시목전연구적열점。본문의취여연골세포화BMSCs상관적기인전염방면（포괄병독재체、단기인전염화다기인전염）취득적성과화최신연구진전작일종술。
As articular cartilage is a non‐vascular tissue composed of chondrocytes and cartilage extracellular matrix ,the ability to repair itself after injury is weak .Using of gene transfection technology for cartilage injury disease is the focus and hotspot of study in gene engineering .Chondrocyte and BMSCs are the uppermost and the most common seed cells of gene transfection technology ,and being correlative with that ,the study of gene transfection is also the hotspot at prensent . This paper reviewed the products and the latest advancements of the study (including virus vector ,single gene transfection and multi‐gene transfection) on gene transfection correlative with chondrocyte and BMSCs .