中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
35期
80-81,86
,共3页
全脑放疗%同步化疗%替莫唑胺%脑转移瘤
全腦放療%同步化療%替莫唑胺%腦轉移瘤
전뇌방료%동보화료%체막서알%뇌전이류
Whole brain radiation therapy%Concurrent chemotherapy%Temozolomide%Brain metastases
目的：观察替莫唑胺联合全脑放射疗法治疗多发脑转移瘤(3~10个病灶)患者的疗效、生存率和不良反应。方法全脑放射治疗30 Gy/3 Gy/10 f/2周，同时替莫唑胺75 mg/(m2·d)连续口服14 d，休息4周后继续替莫唑胺150 mg/(m2·d)辅助治疗6个周期。结果治疗后93.5%患者神经系统症状改善，对脑转移灶的客观有效率为76.1%(35/46)，局部控制率为97.8%(45/46)，中位无进展生存时间为8.5个月，中位总生存时间为13.3个月，一年生存率为54.3%(25/46)，不良反应主要为Ⅰ~Ⅱ级胃肠道反应、中性粒细胞减少、脱发、疲乏、头痛、焦虑等。结论替莫唑胺同步全脑放疗治疗脑转移瘤的有效率和生存率均较高，且安全有效。
目的：觀察替莫唑胺聯閤全腦放射療法治療多髮腦轉移瘤(3~10箇病竈)患者的療效、生存率和不良反應。方法全腦放射治療30 Gy/3 Gy/10 f/2週，同時替莫唑胺75 mg/(m2·d)連續口服14 d，休息4週後繼續替莫唑胺150 mg/(m2·d)輔助治療6箇週期。結果治療後93.5%患者神經繫統癥狀改善，對腦轉移竈的客觀有效率為76.1%(35/46)，跼部控製率為97.8%(45/46)，中位無進展生存時間為8.5箇月，中位總生存時間為13.3箇月，一年生存率為54.3%(25/46)，不良反應主要為Ⅰ~Ⅱ級胃腸道反應、中性粒細胞減少、脫髮、疲乏、頭痛、焦慮等。結論替莫唑胺同步全腦放療治療腦轉移瘤的有效率和生存率均較高，且安全有效。
목적：관찰체막서알연합전뇌방사요법치료다발뇌전이류(3~10개병조)환자적료효、생존솔화불량반응。방법전뇌방사치료30 Gy/3 Gy/10 f/2주，동시체막서알75 mg/(m2·d)련속구복14 d，휴식4주후계속체막서알150 mg/(m2·d)보조치료6개주기。결과치료후93.5%환자신경계통증상개선，대뇌전이조적객관유효솔위76.1%(35/46)，국부공제솔위97.8%(45/46)，중위무진전생존시간위8.5개월，중위총생존시간위13.3개월，일년생존솔위54.3%(25/46)，불량반응주요위Ⅰ~Ⅱ급위장도반응、중성립세포감소、탈발、피핍、두통、초필등。결론체막서알동보전뇌방료치료뇌전이류적유효솔화생존솔균교고，차안전유효。
Objective To observe the clinical efficacy,survival and adverse reactions of temozolomide (TMZ)combined with whole brain radiation therapy on multiple brain metastases (3-10 lesions). Methods Whole brain radiation therapy was carried out of 30 Gy/3 Gy/10 f/2 weeks,at the same time,TMZ 75 mg/(m2·d) was taken orally for 14 days,after 4 weeks rest,TMZ 150 mg/(m2·d) was used for adjuvant therapy for 6 weeks. Results After treatment,the neurological symptoms of 93.5% patients were improved.The objective response rate of brain metastases was 76.1%(35/46),the local control rate was 97.8%(45/46),the median progression-free survival time was 8.5 months,overall survival time was 13.3 months,1-year survival rate was 54.3%(25/46).The adverse reactions were grade Ⅰ-II gastrointestinal reactions,leu-copenia,alopecia,fatigue,headache,anxiety,etc. Conclusion TMZ combined with whole brain radiation therapy in the treatment of multiple brain metastases has higher efficiency and survival rate,it is safe and effective.
