中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
35期
66-67,70
,共3页
宫颈上皮内瘤变%人乳头状瘤病毒%宫颈锥切术%相关因素
宮頸上皮內瘤變%人乳頭狀瘤病毒%宮頸錐切術%相關因素
궁경상피내류변%인유두상류병독%궁경추절술%상관인소
Cervical intraepithelial neoplasia%Human papillomavirus%Cervical conization%Related factors
目的：探讨宫颈上皮内瘤变(CIN)患者人类乳头瘤病毒(HPV)感染亚型特点，分析宫颈锥切术后HPV感染转阴的相关因素。方法选择本院接受两癌筛查HPV阳性的544例妇女为研究对象，回顾性分析HPV感染亚型分布特点，经病理确诊的CIN2和CIN3的患者采取宫颈锥切术治疗，探讨术后HPV感染转阴的相关因素。结果前3位感染亚型是HPV52型、HPV16型和HPV58型，分别占18.20%、13.05%和12.5%；宫颈锥切术后半年HPV转阴率为76.58%，单因素分析提示年龄、受教育程度、产次、病变程度、累及腺体和术后应用抗炎药与HPV转阴均无明显相关性，多因素分析提示术后性生活与HPV转阴存在相关性。结论CIN患者以HPV52、HPV16型和HPV58型感染为主，宫颈锥切术治疗CIN效果明显，术后性生活可能是影响HPV感染转阴的相关因素。
目的：探討宮頸上皮內瘤變(CIN)患者人類乳頭瘤病毒(HPV)感染亞型特點，分析宮頸錐切術後HPV感染轉陰的相關因素。方法選擇本院接受兩癌篩查HPV暘性的544例婦女為研究對象，迴顧性分析HPV感染亞型分佈特點，經病理確診的CIN2和CIN3的患者採取宮頸錐切術治療，探討術後HPV感染轉陰的相關因素。結果前3位感染亞型是HPV52型、HPV16型和HPV58型，分彆佔18.20%、13.05%和12.5%；宮頸錐切術後半年HPV轉陰率為76.58%，單因素分析提示年齡、受教育程度、產次、病變程度、纍及腺體和術後應用抗炎藥與HPV轉陰均無明顯相關性，多因素分析提示術後性生活與HPV轉陰存在相關性。結論CIN患者以HPV52、HPV16型和HPV58型感染為主，宮頸錐切術治療CIN效果明顯，術後性生活可能是影響HPV感染轉陰的相關因素。
목적：탐토궁경상피내류변(CIN)환자인류유두류병독(HPV)감염아형특점，분석궁경추절술후HPV감염전음적상관인소。방법선택본원접수량암사사HPV양성적544례부녀위연구대상，회고성분석HPV감염아형분포특점，경병리학진적CIN2화CIN3적환자채취궁경추절술치료，탐토술후HPV감염전음적상관인소。결과전3위감염아형시HPV52형、HPV16형화HPV58형，분별점18.20%、13.05%화12.5%；궁경추절술후반년HPV전음솔위76.58%，단인소분석제시년령、수교육정도、산차、병변정도、루급선체화술후응용항염약여HPV전음균무명현상관성，다인소분석제시술후성생활여HPV전음존재상관성。결론CIN환자이HPV52、HPV16형화HPV58형감염위주，궁경추절술치료CIN효과명현，술후성생활가능시영향HPV감염전음적상관인소。
Objective To investigate the subtype features of human papillomavirus (HPV) infection in patients with cer-vical intraepithelial neoplasia (CIN),and analyze the related factors of negative HPV infection after conization. Methods 554 cases of women received two cancer screening in our hospital with positive HPV were selected,the subtype features of HPV infection was retrospectively analyzed,conization was taken to patients with CIN2 and CIN 3 confirmed by pathology,the related factors of negative HPV infection was investigated. Results HPV52,HPV16 and HPV58 were the first three subtypes of infection,was 18.20%,13.05%and 12.5%respectively.HPV negative rate underwent transanal was 76.58%.Univariate analysis showed that age,level of education,parity,severity,involving glands and postoperative anti-inflammatory drugs had no significant correlation with HPV negative.Multivariate analysis showed that postoperative sexual life had significant correlation with HPV negative. Conclusion HPV16 subtypes is the major infections status of patients with CIN.Cervical conization has an obvious efficacy for CIN.Postoperative sexual life maybe the risk factors for HPV negative.
