CAJ | 학술논문

目的：观察并探讨中药复方对冠心病治疗性血管新生的作用。方法：选择实验用大鼠30只作为本次实验对象，将大鼠随机分为观察1组、观察2组与对照组3组，每组10只。观察1组作为中药组，观察2组为贝复济组，对照组为空白组。作大鼠心肌缺血实验模型，术后分别给药，观察3组大鼠EC、CD、VEGF及bFGF表达。结果：观察1组、观察2组大鼠CD与EC分布且与对照组比较，具有显著性差异（P<0.05）；观察1组与观察2组VEGF及bFGF反应与对照组比较，结果具有显著性差异（P<0.05）。结论：中药复方可促进冠心病治疗性血管新生作用，其在临床上的应用还有待于进一步临床验证。
목적：관찰병탐토중약복방대관심병치료성혈관신생적작용。방법：선택실험용대서30지작위본차실험대상，장대서수궤분위관찰1조、관찰2조여대조조3조，매조10지。관찰1조작위중약조，관찰2조위패복제조，대조조위공백조。작대서심기결혈실험모형，술후분별급약，관찰3조대서EC、CD、VEGF급bFGF표체。결과：관찰1조、관찰2조대서CD여EC분포차여대조조비교，구유현저성차이（P<0.05）；관찰1조여관찰2조VEGF급bFGF반응여대조조비교，결과구유현저성차이（P<0.05）。결론：중약복방가촉진관심병치료성혈관신생작용，기재림상상적응용환유대우진일보림상험증。
Objective:To observe and analyze clinical effects of TCM medicine on coronary heart disease therapeutic angiogenesis. Methods:30 rats were randomly divided into the observation group 1 (TCM medicine group), the observation group 2 (bFGF group) and the control group (blank group). Myocardial ischemia modes were made, EC,CD, VEGF and bFGF expression of rats in three groups were observed. Results: CD, EC distribution in the observation 1 and the observation 2 has statistically significant compared with the control group (P<0.05);the same as VEGF and bFGF reactions (P<0.05). Conclusion:TCM medicine can improve the function of coronary heart disease therapeutic angiogenesis, its application needs more examination.