CAJ | 학술논문

目的：观察不同化疗方案治疗初治结核性脑膜炎的疗效。方法将第三军医大学新桥医院神经内科收治的65例结核性脑膜炎患者分为 A组（n＝22）、B组（n＝21）和C组（n＝22），分别按3HRZE／15HRE、3HRZS／15HRE和3HRZL／15HRL方案治疗，同时给予其他辅助治疗。比较3组的临床疗效、临床表现持续时间、脑脊液生化指标和并发症发生率。结果 A组和 C组临床疗效明显优于B组（P＜0．05），A组和C组临床疗效差异无统计学意义（P＞0．05）；A组、C组在2周内改善结核中毒症状方面明显优于B组（P＜0．05），在缩短脑积水和脑膜刺激征持续时间的绝对病例数多于 B组，差异无统计学意义（P＞0．05）。A组和C组的脑脊液蛋白含量、氯化物和葡萄糖与B组比较有明显改善（P＜0．05）；A组和 C组并发症发生率明显低于 B组（P＜0．05）。结论3HRZE／15HRE和3HRZL／15HRL方案治疗初治结核性脑膜炎有较好临床疗效。
목적：관찰불동화료방안치료초치결핵성뇌막염적료효。방법장제삼군의대학신교의원신경내과수치적65례결핵성뇌막염환자분위 A조（n＝22）、B조（n＝21）화C조（n＝22），분별안3HRZE／15HRE、3HRZS／15HRE화3HRZL／15HRL방안치료，동시급여기타보조치료。비교3조적림상료효、림상표현지속시간、뇌척액생화지표화병발증발생솔。결과 A조화 C조림상료효명현우우B조（P＜0．05），A조화C조림상료효차이무통계학의의（P＞0．05）；A조、C조재2주내개선결핵중독증상방면명현우우B조（P＜0．05），재축단뇌적수화뇌막자격정지속시간적절대병례수다우 B조，차이무통계학의의（P＞0．05）。A조화C조적뇌척액단백함량、록화물화포도당여B조비교유명현개선（P＜0．05）；A조화 C조병발증발생솔명현저우 B조（P＜0．05）。결론3HRZE／15HRE화3HRZL／15HRL방안치료초치결핵성뇌막염유교호림상료효。
Objective To investigate the therapeutic effect of different chemotherapeutical schedule for initial treatment tubercu-lous meningitis.Methods A total of 65 cases of tuberculous meningitis that from the department of the third people′s hospital of Chongqing were divided into group A (n=22),group B (n=21)and group C (n=22),and received 3HRZE/15HRE,3HRZS/15HRE and 3HRZL/15HRL therapeutic schedule respectively.At the same time,other adjunctive therapy was gave,so as to con-trast the therapeutic effects,clinical features duration,biochemical indicator of cerebrospinal fluid and incidence rate of complication in 3 groups.Results The therapeutic effect of group A and group C were superior to that of group B significantly (P<0.05),there were no significant differences between group A and group C (P>0.05),and were more than group B in the absolute number of ca-ses of shorten the hydrocephalus and meningeal irritation duration,But the difference with no statistically significant(P>0.05);group A and group C were superior to group B in duration of tuberculosis toxic symptom(P<0.05).group A and group C were su-perior to group B significantly in improving content of protein,chloride and glucose (P<0.05).The occurrence rate of group A and group C were lower than that of group B(P<0.05).Conclusion Both 3HRZE/15HRE and 3HRZL/15HRL therapeutic schedule have therapeutic effect on initial treatment tuberculous meningitis.