重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
34期
4610-4612
,共3页
囊胚培养%冻融胚胎%囊胚移植%临床妊娠率%种植率
囊胚培養%凍融胚胎%囊胚移植%臨床妊娠率%種植率
낭배배양%동융배태%낭배이식%림상임신솔%충식솔
blastocyst culture%frozen-thawed embryo%blastocyst transfer%clinical pregnancy rate%implantation rate
目的：探讨冻融囊胚移植、冻融卵裂期胚胎复苏后行囊胚移植的临床价值。方法回顾性分析2012年9月至2013年8月在该院生殖医学中心接受冻融胚胎移植治疗患者共518个周期的临床资料，按移植冻融胚胎类型分为3组。A组：冻融囊胚移植，共129个周期；B组：卵裂期胚胎复苏后行囊胚培养后移植，共123个周期；C组（对照）：冻融卵裂胚移植，共266个周期。比较各组的临床结局及 A、B两组间新鲜周期胚胎和冻融周期的囊胚形成率和取消率。结果 A、B组的生化妊娠率、临床妊娠率和胚胎种植率（70．5％、61．2％、42．3％；67．5％、58．2％、40．2％）显著高于 C组（53．0％、42．5％、23．1％）（P＜0．05）；3组间流产率、异位妊娠率、多胎妊娠率差异无统计学意义（P＞0．05）。新鲜周期第3天优质胚胎与冻融胚胎复苏后的囊胚形成率（62．5％vs．57．7％）差异无统计学意义（P＞0．05），均显著高于新鲜周期第3天非优质胚胎的囊胚形成率（20．3％）（P＜0．05）。结论冻融周期行囊胚移植可以获得较满意的临床结局；冻融卵裂期胚胎行囊胚培养后可获得较高的囊胚形成率和临床结局。
目的：探討凍融囊胚移植、凍融卵裂期胚胎複囌後行囊胚移植的臨床價值。方法迴顧性分析2012年9月至2013年8月在該院生殖醫學中心接受凍融胚胎移植治療患者共518箇週期的臨床資料，按移植凍融胚胎類型分為3組。A組：凍融囊胚移植，共129箇週期；B組：卵裂期胚胎複囌後行囊胚培養後移植，共123箇週期；C組（對照）：凍融卵裂胚移植，共266箇週期。比較各組的臨床結跼及 A、B兩組間新鮮週期胚胎和凍融週期的囊胚形成率和取消率。結果 A、B組的生化妊娠率、臨床妊娠率和胚胎種植率（70．5％、61．2％、42．3％；67．5％、58．2％、40．2％）顯著高于 C組（53．0％、42．5％、23．1％）（P＜0．05）；3組間流產率、異位妊娠率、多胎妊娠率差異無統計學意義（P＞0．05）。新鮮週期第3天優質胚胎與凍融胚胎複囌後的囊胚形成率（62．5％vs．57．7％）差異無統計學意義（P＞0．05），均顯著高于新鮮週期第3天非優質胚胎的囊胚形成率（20．3％）（P＜0．05）。結論凍融週期行囊胚移植可以穫得較滿意的臨床結跼；凍融卵裂期胚胎行囊胚培養後可穫得較高的囊胚形成率和臨床結跼。
목적：탐토동융낭배이식、동융란렬기배태복소후행낭배이식적림상개치。방법회고성분석2012년9월지2013년8월재해원생식의학중심접수동융배태이식치료환자공518개주기적림상자료，안이식동융배태류형분위3조。A조：동융낭배이식，공129개주기；B조：란렬기배태복소후행낭배배양후이식，공123개주기；C조（대조）：동융란렬배이식，공266개주기。비교각조적림상결국급 A、B량조간신선주기배태화동융주기적낭배형성솔화취소솔。결과 A、B조적생화임신솔、림상임신솔화배태충식솔（70．5％、61．2％、42．3％；67．5％、58．2％、40．2％）현저고우 C조（53．0％、42．5％、23．1％）（P＜0．05）；3조간유산솔、이위임신솔、다태임신솔차이무통계학의의（P＞0．05）。신선주기제3천우질배태여동융배태복소후적낭배형성솔（62．5％vs．57．7％）차이무통계학의의（P＞0．05），균현저고우신선주기제3천비우질배태적낭배형성솔（20．3％）（P＜0．05）。결론동융주기행낭배이식가이획득교만의적림상결국；동융란렬기배태행낭배배양후가획득교고적낭배형성솔화림상결국。
Objective To evaluate the clinical value of frozen-thawed blastocyst transfer and the blastocyst derived from frozen-thawed cleavage stage embryo transfer.Methods The data of 5 1 8 cycles in reproductive medicine center of the hospital from Sep-tember 2012 to August 2013 were analyzed retrospectively.According to the frozen-embryos type,all patients were divided into three groups,group A:frozen-thawed blastocyst transfer,129 cycles;group B:blastocysts derived from frozen-thawed cleavage stage embryos transfer,123 cycles;group C:frozen-thawed cleavage embryos transfer,266 cycles.The clinical outcomes of all groups were compared with each other,and the rates of blastocyst formation and cancellation were compared between group A and group B.Re-sults The rates of biochemical pregnancy,clinical pregnancy and embryo implantation in group A(70.5%,61.2%,42.3%)and group B(67.5%,58.2%,40.2%)were significantly higher than group C(53.0%,42.5%,23.1%)(P<0.05);there were no signif-icant differences in the rates of early abortion,ectopic pregnancy,multiple pregnancy among three groups(P>0.05);there were no significant differences in the blastocyst formation rates of the high quality cleavage embryos at D3 in fresh cycles and the frozen-thawed cleavage embryos(62.5%vs.57.7%)(P>0.05)and those two groups were both significantly higher than the poor quality cleavage embryos at D3 in fresh cycles(20.3%)(P<0.05).Conclusion Blastocyst transfer in vitrified-thawed cycles could get rel-atively satisfactory clinical outcomes.There are higher blastocyst formation rate and better clinical outcomes of transfer blastocyst derived from frozen-thawed cleavage embryo.
