CAJ | 학술논문

目的：探讨母体血清C反应蛋白在诊断早发性新生儿败血症（EONS）中的作用。方法以该院2010年1月至2013年6月收治的65例早产新生儿（妊娠28～36周）及其母亲为研究对象，新生儿分成败血症组（n＝28）和对照组（n＝37）。免疫比浊法测定产妇分娩72 h内血清C反应蛋白的水平，建立C反应蛋白水平 ROC曲线，将母亲分为C反应蛋白阳性组（≥1．35 mg／dL，n＝25）和C反应蛋白阴性组（＜1．35 mg／dL，n＝40），比较母体血清C反应蛋白水平与早发性新生儿败血症的关系。结果新生儿败血症组母体血清C反应蛋白水平显著高于对照组[（3．61±2．85）mg／dL vs．（0．82±0．73）mg／dL，P＜0．01]。母体血清C反应蛋白预测新生儿败血症灵敏度和特异度分别为72．0％和83．0％，母体血清C反应蛋白阳性组新生儿败血症发病率明显高于C反应蛋白阴性组（71．4％vs．28．6％，P＜0．01），其新生儿患败血症的危险系数是母体 C反应蛋白阴性组的10．54倍（P＜0．01）。结论母体血清C反应蛋白升高与早发性新生儿败血症显著相关，母体血清 C反应蛋白可作为早期诊断早发性新生儿败血症的指标。
목적：탐토모체혈청C반응단백재진단조발성신생인패혈증（EONS）중적작용。방법이해원2010년1월지2013년6월수치적65례조산신생인（임신28～36주）급기모친위연구대상，신생인분성패혈증조（n＝28）화대조조（n＝37）。면역비탁법측정산부분면72 h내혈청C반응단백적수평，건립C반응단백수평 ROC곡선，장모친분위C반응단백양성조（≥1．35 mg／dL，n＝25）화C반응단백음성조（＜1．35 mg／dL，n＝40），비교모체혈청C반응단백수평여조발성신생인패혈증적관계。결과신생인패혈증조모체혈청C반응단백수평현저고우대조조[（3．61±2．85）mg／dL vs．（0．82±0．73）mg／dL，P＜0．01]。모체혈청C반응단백예측신생인패혈증령민도화특이도분별위72．0％화83．0％，모체혈청C반응단백양성조신생인패혈증발병솔명현고우C반응단백음성조（71．4％vs．28．6％，P＜0．01），기신생인환패혈증적위험계수시모체 C반응단백음성조적10．54배（P＜0．01）。결론모체혈청C반응단백승고여조발성신생인패혈증현저상관，모체혈청 C반응단백가작위조기진단조발성신생인패혈증적지표。
Objective To evaluate the diagnostic performance of C reactive protein(CRP)in predicting early onset neonatal sep-sis.Methods Those in the study were 65 preterm singleton neonates(gestational age at delivery was 28-36 weeks)and their moth-ers in the hospital from January 2010 to June 2013 and the neonate were divided into sepsis group(n=28)and controls(n=37).Im-munoturbidimetry was adopted to detect the CRP measurement within 72 h after delivered,the ROC curve of maternal CRP was used,mothers were divided into CRP positive group(CRP≥1.35 mg/dL,n=25)and CRP negative group(CRP<1.35 mg/dL,n=78),comparing the relationship between maternal serum CRP level and early-onset neonatal sepsis.Results Maternal CRP was sig-nificantly higher in neonatal sepsis group than that in control group[(3.61±2.85)mg/dL vs.(0.82±0.73)mg/dL,P<0.01].The sensitivity,specificity of maternal serum CRP level were 72.0% and 83.0% for predicting neonatal sepsis.Incidence of neonatal sepsis in maternal CRP positive group was significantly higher than that of maternal CRP negative group(71.4% vs.28.6%,P<0.01)and the relative risk of neonatal sepsis was 10.54 times that of the maternal CRP negative group(P<0.01).Conclusion The elevated levels of maternal serum CRP were significantly associated with early onset neonatal sepsis.Maternal CRP could be used for early diagnosis of early-onset neonatal sepsis.