CAJ | 학술논문

目的：观察肺结核合并糖尿病患者血清 IL-2、TNF-α的表达，并初步探讨其临床意义。方法试验分为对照组（门诊健康体检者，n＝10）、肺结核组（n＝20）、糖尿病组（n＝20）和肺结核合并糖尿病组（n＝20），治疗2个月后根据病情转归将肺结核合并糖尿病组分为好转组及恶化组，ELISA法检测血清中 IL-2、TNF-α水平。结果治疗前：肺结核组、糖尿病组、肺结核合并糖尿病组血清 IL-2水平均降低（P＜0．05），其中肺结核合并糖尿病组低于肺结核组和糖尿病组（P＜0．05）；肺结核合并糖尿病组、肺结核组、糖尿病组血清TNF-α水平均升高（P＜0．05），其中肺结核合并糖尿病组高于糖尿病组（P＜0．05）；治疗后：肺结核合并糖尿病好转组血清 IL-2水平上升，而TNF-α水平有明显下降（P＜0．05），恶化组治疗前后变化不明显（P＞0．05）。结论IL-2、TNF-α在肺结核合并糖尿病的免疫发病机制中起着一定的作用，其动态变化能反应肺结核合并糖尿病的病情发展及转归。
목적：관찰폐결핵합병당뇨병환자혈청 IL-2、TNF-α적표체，병초보탐토기림상의의。방법시험분위대조조（문진건강체검자，n＝10）、폐결핵조（n＝20）、당뇨병조（n＝20）화폐결핵합병당뇨병조（n＝20），치료2개월후근거병정전귀장폐결핵합병당뇨병조분위호전조급악화조，ELISA법검측혈청중 IL-2、TNF-α수평。결과치료전：폐결핵조、당뇨병조、폐결핵합병당뇨병조혈청 IL-2수평균강저（P＜0．05），기중폐결핵합병당뇨병조저우폐결핵조화당뇨병조（P＜0．05）；폐결핵합병당뇨병조、폐결핵조、당뇨병조혈청TNF-α수평균승고（P＜0．05），기중폐결핵합병당뇨병조고우당뇨병조（P＜0．05）；치료후：폐결핵합병당뇨병호전조혈청 IL-2수평상승，이TNF-α수평유명현하강（P＜0．05），악화조치료전후변화불명현（P＞0．05）。결론IL-2、TNF-α재폐결핵합병당뇨병적면역발병궤제중기착일정적작용，기동태변화능반응폐결핵합병당뇨병적병정발전급전귀。
Objective To investigate the expression of serum interleukin-2(IL-2),tumor necrosis factor-α(TNF-α)in the pa-tients with pulmonary tuberculosis and diabetes,and prelininary explore its clinical significance.Methods Experiment were divided into control group(health check-up outpatient,n=10),pulmonary tuberculosis group(n=20),diabetes group(n=20),tuberculosis combine diabetes group(n=20),tuberculosis combine diabetes group was divided into improved group,diabetes group and deterio-rated group after 2 months with therapy according to disease outcome,ELISA assay was used to measured the level of serum IL-2 and TNF-α.Results Before treatment:serum IL-2 levels of pulmonary tuberculosis group,diabetes group and pulmonary tuberculo-sis combine diabetes group were reduced (P<0.05),and the pulmonary tuberculosis group was lower than the pulmonary tubercu-losis group and diabetes group (P<0.05);serum TNF-αlevels of pulmonary tuberculosis combine diabetes group,pulmonary tu-berculosis group and diabetes group increased (P<0.05),and that of pulmonary tuberculosis combine diabetes group was higher than that of diabetes group (P<0.05).After treatment:the level of serum IL-2 increased and TNF-αsignificantly decreased in pul-monary tuberculosis combine diabetes improved group (P<0.05),the deterioration group had no change(P>0.05).Conclusion IL-2 and TNF-αplay a role in the immune pathogenesis of tuberculosis combine diabetes,which dynamic changes can reflect the progression and outcome of pulmonary tuberculosis combine diabetes.