CAJ | 학술논문

目的：探讨重庆地区汉族人群中 IL-10基因型与幽门螺杆菌相关的胃癌易感性的关系。方法选取幽门螺杆菌阳性的胃癌患者（胃癌组）100例和体检者中的幽门螺杆菌感染者（对照组）140例，采用限制性片段长度多态性 PCR（PCR-RFLP）的方法检测重庆地区汉族人群中IL-10-592位点多态性。结果与对照组比较，胃癌组IL-10-592各基因型的频率分布差异有统计学意义（χ2＝16．36，P＜0．05）。经 Logistic回归分析，与携带IL-10-592 C／C者比较，携带IL-10-592 A／A者发生胃癌的危险性为OR＝4．37（95％CI：2．04～9．38）。结论 IL-10基因多态性与幽门螺杆菌相关胃癌有关，IL-10-592是幽门螺杆菌相关胃癌的易感基因。
목적：탐토중경지구한족인군중 IL-10기인형여유문라간균상관적위암역감성적관계。방법선취유문라간균양성적위암환자（위암조）100례화체검자중적유문라간균감염자（대조조）140례，채용한제성편단장도다태성 PCR（PCR-RFLP）적방법검측중경지구한족인군중IL-10-592위점다태성。결과여대조조비교，위암조IL-10-592각기인형적빈솔분포차이유통계학의의（χ2＝16．36，P＜0．05）。경 Logistic회귀분석，여휴대IL-10-592 C／C자비교，휴대IL-10-592 A／A자발생위암적위험성위OR＝4．37（95％CI：2．04～9．38）。결론 IL-10기인다태성여유문라간균상관위암유관，IL-10-592시유문라간균상관위암적역감기인。
Objective To discuss the relationship between IL-10 genes and susceptibility of H.pylori-associated gastric cancer of Han population in Chongqing district.Methods 100 H.pylori-positive patients with gastric cancer(gastric cancer group)and 140 H.pylori-positive healthy people (control group)were chose in the study,PCR-RFLP method was used to detect the IL-10-592 lo-cus polymorphisms of Han population in Chongqing district.Results Comparing with control group,IL-10-592 genotype frequency distribution of gastric cancer group has statistically significance (χ2=16.36,P<0.05).Logistic regression analysis showed that gastric cancer incidence risk of people carrying with IL-10-592 A/A genotype was OR=4.37(95%CI:2.04-9.38),comparing with the subjects carrying with IL-10-592 C/C.Conclusion Polymorphism of IL-10 gene has close correlated with H.pylori-asso-ciated gastric cancer,IL-10-592 C/C might be the susceptibility gene of H.pylori-associated gastric cancer.