CAJ | 학술논문

糖尿病肾病（diabetic nephropathy，DN）是糖尿病微血管病变中最常见的严重并发症之一，近年来DN逐步成为终末期肾病（end stage renal disease，ESRD）的首要原因，但是DN的发病机制迄今为止尚未完全阐明。蛋白尿是DN的主要临床特征，也是导致DN恶性进展的重要因素。近年研究认为，足细胞表型转化可能是导致DN早期蛋白尿形成的关键因素。基于此，本文对足细胞表型转化的相关生物学特点、信号通路、与蛋白尿之间关系以及缬沙坦和雷公藤内酯醇干预表型转化可能存在的机制进行综述。
당뇨병신병（diabetic nephropathy，DN）시당뇨병미혈관병변중최상견적엄중병발증지일，근년래DN축보성위종말기신병（end stage renal disease，ESRD）적수요원인，단시DN적발병궤제흘금위지상미완전천명。단백뇨시DN적주요림상특정，야시도치DN악성진전적중요인소。근년연구인위，족세포표형전화가능시도치DN조기단백뇨형성적관건인소。기우차，본문대족세포표형전화적상관생물학특점、신호통로、여단백뇨지간관계이급힐사탄화뢰공등내지순간예표형전화가능존재적궤제진행종술。
Diabetic nephropathy (DN) is one of the most common and severe complications of diabetic microangiopa-thy which gradually become the major cause of end-stage renal disease (ESRD) in recent years, even though its patho-genesis remains to be elucidated. Proteinuria is one of important malignant factors leading to the deterioration of DN as well as its mainly clinical feature. Lately experimental evidences show that podocyte phenotypic transformation could be a causative role in the genesis of the early DN proteinuria. In this context, it ’s necessary to review the relative bio-logical characteristics of podocyte phenotypic transformation, its associated signaling pathways, its relationship between proteinuria and the possible mechanism of its medical intervention including valsartan and triptolide.