CAJ | 학술논문

目的：探讨HIF-1α与VEGF在稽留流产及正常早期妊娠绒毛组织中的表达及意义。方法选择早期妊娠（对照组）及稽留流产（实验组）患者各50例，用免疫组化SABC法分别检测两组患者绒毛组织中HIF-1α与VEGF的表达情况。结果HIF-1α在对照组中表达阳性率为42%，在实验组表达阳性率为76%，差异有统计学意义（P<0.05）；VEGF在对照组中表达阳性率为100%，在实验组表达阳性率为66%，差异有统计学意义（P<0.05）。实验组中HIF-1α和VEGF的表达无明显相关关系（r=-0.298，P>0.05）；对照组中HIF-1α与VEGF的表达呈正相关（r=0.387，P<0.05）。结论 HIF-1α及VEGF表达异常可能与稽留流产发生有关。
목적：탐토HIF-1α여VEGF재계류유산급정상조기임신융모조직중적표체급의의。방법선택조기임신（대조조）급계류유산（실험조）환자각50례，용면역조화SABC법분별검측량조환자융모조직중HIF-1α여VEGF적표체정황。결과HIF-1α재대조조중표체양성솔위42%，재실험조표체양성솔위76%，차이유통계학의의（P<0.05）；VEGF재대조조중표체양성솔위100%，재실험조표체양성솔위66%，차이유통계학의의（P<0.05）。실험조중HIF-1α화VEGF적표체무명현상관관계（r=-0.298，P>0.05）；대조조중HIF-1α여VEGF적표체정정상관（r=0.387，P<0.05）。결론 HIF-1α급VEGF표체이상가능여계류유산발생유관。
Objective To investigate the association of HIF-1αand VEGF signaling in missed abortion. Methods Fifty patients with missed abortion were selected as study group, and fifty early pregnant women who underwent artificial abortion surgery were selected as control group. The expressions of HIF-1α and VEGF were measured by immunohis-tochemistry. Results The expressive rate of VEGF was 100%in the control group and 66% in the study group. The ex-pressive rate of HIF-1α was 42% in the control group and 76% in the study group. Compared with the control group, the expression of VEGF was statistically reduced(P<0.05) while the level of HIF-1α was significantly up-regulated(P<0.05)in the study group. In the control group, HIF-1αwas positively correlated with VEGF(r=0.387,P<0.05), while in the study group HIF-1α was close negatively correlated with VEGF(r=-0.298,P>0.05). Conclusion The decrease of VEGF and increase of HIF-1αin villous trophoblastic cells may be signals of occurrence of missed abortion.