中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
35期
79-82
,共4页
垂体后叶素%缩宫素%子宫肌瘤%Meta分析
垂體後葉素%縮宮素%子宮肌瘤%Meta分析
수체후협소%축궁소%자궁기류%Meta분석
Pituitrin%Oxytocin%Uterine myoma%Meta-analysis
目的：评价垂体后叶素与缩宫素在腹腔镜下子宫肌瘤剔除术所起的作用与副反应，以阐明两种药物的临床应用价值。方法用计算机检索相关数据库，收集垂体后叶素与缩宫素在腹腔镜下子宫肌瘤剔除术应用的随机对照试验，对符合纳入标准的临床研究进行Meta分析。结果共纳入22篇文献，垂体后叶素较缩宫素效果好，缩短手术时间（MD=-28，95%CI-21～-35，P<0.01），减少术中出血量（MD=-51，95%CI-32～-70，P<0.01），降低术后血红蛋白下降幅度（MD=-3.8，95%CI-2.3～-5.2，P<0.01），但患者血压升高发生率高（OR=2.25，95%CI 1.90～2.60，P<0.01）。结论垂体后叶素在腹腔镜下子宫肌瘤剔除术的应用可缩短手术时间，减少术中出血量，降低术后血红蛋白下降幅度，但患者血压升高的发生率明显高于缩宫素，因此，严密控制用药指征显得更为重要。
目的：評價垂體後葉素與縮宮素在腹腔鏡下子宮肌瘤剔除術所起的作用與副反應，以闡明兩種藥物的臨床應用價值。方法用計算機檢索相關數據庫，收集垂體後葉素與縮宮素在腹腔鏡下子宮肌瘤剔除術應用的隨機對照試驗，對符閤納入標準的臨床研究進行Meta分析。結果共納入22篇文獻，垂體後葉素較縮宮素效果好，縮短手術時間（MD=-28，95%CI-21～-35，P<0.01），減少術中齣血量（MD=-51，95%CI-32～-70，P<0.01），降低術後血紅蛋白下降幅度（MD=-3.8，95%CI-2.3～-5.2，P<0.01），但患者血壓升高髮生率高（OR=2.25，95%CI 1.90～2.60，P<0.01）。結論垂體後葉素在腹腔鏡下子宮肌瘤剔除術的應用可縮短手術時間，減少術中齣血量，降低術後血紅蛋白下降幅度，但患者血壓升高的髮生率明顯高于縮宮素，因此，嚴密控製用藥指徵顯得更為重要。
목적：평개수체후협소여축궁소재복강경하자궁기류척제술소기적작용여부반응，이천명량충약물적림상응용개치。방법용계산궤검색상관수거고，수집수체후협소여축궁소재복강경하자궁기류척제술응용적수궤대조시험，대부합납입표준적림상연구진행Meta분석。결과공납입22편문헌，수체후협소교축궁소효과호，축단수술시간（MD=-28，95%CI-21～-35，P<0.01），감소술중출혈량（MD=-51，95%CI-32～-70，P<0.01），강저술후혈홍단백하강폭도（MD=-3.8，95%CI-2.3～-5.2，P<0.01），단환자혈압승고발생솔고（OR=2.25，95%CI 1.90～2.60，P<0.01）。결론수체후협소재복강경하자궁기류척제술적응용가축단수술시간，감소술중출혈량，강저술후혈홍단백하강폭도，단환자혈압승고적발생솔명현고우축궁소，인차，엄밀공제용약지정현득경위중요。
Objective To evaluate efficacy and side effect profile of pituitrin or oxytocin in the laparoscopic myomecto-my,and further to elucidate the clinical value of the two drugs. Methods Searched in the electronic database to get randomized controlled trials about the effect of pituitrin or oxytocin for laparoscopic myomectomy. Data which accord with the standard clinical studies were analyzed by Meta analysis. Results A total of 22 articles were included in the study. The results of meta analysis showed that pituitrin was more effective than oxytocin in the control of the operation time(MD=-28,95%CI-21~-35), reduced the amount of bleeding(MD=-51,95%CI-32~-70), reduced the postoper-ative hemoglobin decrease(MD=-3.8,95%CI-2.3~-5.2). But the side effects of high blood pressure in pituitrin group were more serious than that in the oxytocin group(OR=2.25,95%CI 1.90~2.60). Conclusion Pituitrin in the application of laparoscopic myomectomy could shorten the operation time , reduce intraoperative blood loss , lower postoperative hemoglobin decreased, but the probability of occurrence of high blood pressure in patients with significantly higher than that of oxytocin, strictly grasp the operation indication and contraindication is to improve the surgical success rate and reduce complications.
