CAJ | 학술논문

目的：观察非小细胞肺癌（NSCLC）患者化学治疗前后血清乳腺癌耐药基因ABCG2水平的变化，探讨其临床意义。方法收集15例健康者和50例NSCLC患者化学治疗前后的血清，用ELISA方法检测血清中ABCG2水平，并分析其与化学治疗疗效的关系。结果 NSCLC患者化学治疗前血清 ABCG2水平高于健康者（ P＜0．05）；血清 ABCG2水平与 NSCLC患者TNM 分期无关（P＜0．05）；化学治疗后血清ABCG2水平高于化学治疗前（P＜0．05）；化学治疗有效者化学治疗前后血清ABCG2水平差异无统计学意义（P＞0．05）；化学治疗无效者化学治疗后血清 ABCG2水平高于化学治疗前（P＜0．05）；有胸水患者血清ABCG2水平高于无胸水患者，但差异无统计学意义（P＞0．05）。结论 NSCLC患者血清ABCG2水平高于健康者；血清ABCG2水平可能成为预测NSCLC化学治疗疗效的有用指标。
목적：관찰비소세포폐암（NSCLC）환자화학치료전후혈청유선암내약기인ABCG2수평적변화，탐토기림상의의。방법수집15례건강자화50례NSCLC환자화학치료전후적혈청，용ELISA방법검측혈청중ABCG2수평，병분석기여화학치료료효적관계。결과 NSCLC환자화학치료전혈청 ABCG2수평고우건강자（ P＜0．05）；혈청 ABCG2수평여 NSCLC환자TNM 분기무관（P＜0．05）；화학치료후혈청ABCG2수평고우화학치료전（P＜0．05）；화학치료유효자화학치료전후혈청ABCG2수평차이무통계학의의（P＞0．05）；화학치료무효자화학치료후혈청 ABCG2수평고우화학치료전（P＜0．05）；유흉수환자혈청ABCG2수평고우무흉수환자，단차이무통계학의의（P＞0．05）。결론 NSCLC환자혈청ABCG2수평고우건강자；혈청ABCG2수평가능성위예측NSCLC화학치료료효적유용지표。
Objective To observe the change of the serum ABCG2 level of patients with non‐small cell lung cancer(NSCLC)be‐fore and after chemotherapy ,and explore its clinical significance .Methods Venous blood specimens of 15 healthy adults and 50 pa‐tients with NSCLC were collected before and chemotherapy ,the serum ABCG2 level of these specimens were detected by ELISA . the relation between the ABCG2 level and the chemosensitivity was investigated .Results The serum ABCG2 level of patients with NSCLC before chemotherapy was significantly higher than that in healthy adults(P<0 .05);the serum ABCG2 level was not related with TNM stage in NSCLC(P<0 .05);The serum ABCG2 level of patients with NSCLC after chemotherapy was significantly high‐er than that of before(P<0 .05);in chemosensitive patients ,the different of serum ABCG2 level was not significantly before and af‐ter chemotherapy(P>0 .05);among chemoresistant patients ,the serum ABCG2 level of patients with NSCLC after chemotherapy was significantly higher than that of before(P<0 .05);the serum ABCG2 level was higher in patients with pleural effusion than the patients without pleural effusion ,but the different was not significantly(P>0 .05) .Conclusion The serum ABCG2 level of patients with NSCLC is higher than that of healthy adults ;serum ABCG2 level may become a useful indicator in predicting the effect of NSCLC chemotherapy .