CAJ | 학술논문

目的：评价强化母乳喂养对新生儿监护病房（NICU）住院早产儿的短期生长、内环境的影响及临床安全性。方法入住NICU的早产儿根据不同奶方分为早产奶组、母乳组、强化母乳组（HMF组），比较其生长指标、血生化、不良事件发生率等。结果共147例早产儿符合要求，体质量增长速率在早产奶组、母乳组、HMF组各为（19．44±5．14）、（14．53±5．86）、（17．09±5．81）g·kg－1·d－1，差异有统计学意义（P＜0．01）；头围增长速率在早产奶组（0．72±0．34）cm／w和HMF组（0．71±0．29）cm／w高于母乳组（0．51±0．34）cm／w，差异有统计学意义（P＜0．01）；达到或超过出生体质量时间在早产奶组（8．55±3．20）d和HMF组（9．43±4．53）d患儿中较母乳组（10．93±3．02）d短，差异有统计学意义（P＜0．01）；出院时早产奶组和HMF组的头围宫外生长迟缓（EUGR）发生率明显低于母乳组（P＜0．05）；喂养不耐受率早产奶组（15．52％）高于母乳组（2．13％），差异有统计学意义（P＜0．05）；各组感染发生率比较，差异无统计学意义（P＞0．05）。结论HMF喂养可在有效控制感染和喂养不耐受发生率的前提下优化早产儿院内体质量和头围增长速率。
목적：평개강화모유위양대신생인감호병방（NICU）주원조산인적단기생장、내배경적영향급림상안전성。방법입주NICU적조산인근거불동내방분위조산내조、모유조、강화모유조（HMF조），비교기생장지표、혈생화、불량사건발생솔등。결과공147례조산인부합요구，체질량증장속솔재조산내조、모유조、HMF조각위（19．44±5．14）、（14．53±5．86）、（17．09±5．81）g·kg－1·d－1，차이유통계학의의（P＜0．01）；두위증장속솔재조산내조（0．72±0．34）cm／w화HMF조（0．71±0．29）cm／w고우모유조（0．51±0．34）cm／w，차이유통계학의의（P＜0．01）；체도혹초과출생체질량시간재조산내조（8．55±3．20）d화HMF조（9．43±4．53）d환인중교모유조（10．93±3．02）d단，차이유통계학의의（P＜0．01）；출원시조산내조화HMF조적두위궁외생장지완（EUGR）발생솔명현저우모유조（P＜0．05）；위양불내수솔조산내조（15．52％）고우모유조（2．13％），차이유통계학의의（P＜0．05）；각조감염발생솔비교，차이무통계학의의（P＞0．05）。결론HMF위양가재유효공제감염화위양불내수발생솔적전제하우화조산인원내체질량화두위증장속솔。
Objective To evaluate the effect of human milk fortification on short‐term growth of premature infants in NICU and its clinical safety .Methods According to different formulas ,the premature infants were divided into preterm formula group ,human milk group and human milk fortification group (HMF group) .Its growth rate ,blood biochemistry ,adverse event rate and so on were compared .Results There were 147 cases meeting requirements .the weight growth velocity of preterm formula group ,human milk group and HMF group were (19 .44 ± 5 .14) ,(14 .53 ± 5 .86) ,(17 .09 ± 5 .81) g · kg -1 · d-1 respectively with statistical sig‐nificance (P<0 .01);the growth velocity of head circumference of preterm formula group (0 .72 ± 0 .34)cm/w and HMF group (0 .71 ± 0 .29) cm/w were significantly higher than that of human milk group (0 .51 ± 0 .34)cm/w (P<0 .01);the time of regaining or overtopping birth weight of preterm formula group (8 .55 ± 3 .20)d and HMF group (9 .43 ± 4 .53)d was significantly shorter than that of human milk group (10 .93 ± 3 .02)d(P<0 .01);the EUGR occurrence rate of head circumference of preterm formula group and HMF group were significantly lower than that of human milk group(P<0 .01) .The feeding intolerance rate of preterm formula group (15 .52% ) was significantly higher than that of human milk group (2 .13% ) (P<0 .05);there were no significant difference in incidence rate of infection event in each group(P>0 .05) .Conclusion Human milk fortification can control the inci‐dence rate of infection event and feeding intolerance to increase growth velocity of weight and head circumference of premature in‐fants during hospital stay .