CAJ | 학술논문

目的：观察透明质酸水凝胶对关节软骨缺损的修复效果。方法选取SD大鼠120只，分别编号标记后分为 A组（自然修复组）、B组（透明质酸组）、C组（复合材料组），每组36只，剩余12只用于获取软骨细胞。大鼠股骨滑车全层软骨缺损（直径2．5 mm ，深3．0 mm）模型制备后，分别用不同材料修复，于不同时间点（10、20、40 d）通过组织学及生物化学方法评估修复效果。结果各时间点组织学及生物化学评估C组软骨修复效果最佳，其次为B组，但修复效果均优于A组。结论透明质酸水凝胶与周围组织相容性高，生物降解性好，有利于软骨细胞的存活、繁殖、分裂。
목적：관찰투명질산수응효대관절연골결손적수복효과。방법선취SD대서120지，분별편호표기후분위 A조（자연수복조）、B조（투명질산조）、C조（복합재료조），매조36지，잉여12지용우획취연골세포。대서고골활차전층연골결손（직경2．5 mm ，심3．0 mm）모형제비후，분별용불동재료수복，우불동시간점（10、20、40 d）통과조직학급생물화학방법평고수복효과。결과각시간점조직학급생물화학평고C조연골수복효과최가，기차위B조，단수복효과균우우A조。결론투명질산수응효여주위조직상용성고，생물강해성호，유리우연골세포적존활、번식、분렬。
Objective To observe the repairing effect of hyaluronic acid hydrogel on rat articular cartilage defects .Methods One hundred and twenty SD rats were randomly divided into group A (natural repair group) ,group B (hyaluronic acid group) and group C (composite material group) ,36 rats was in each group and 12 rats were used to obtain cartilage cells .Full‐thickness articular os‐teochondral defects(2 .5 mm in diameter and 3 .0 mm in depth)were created mechanically in femoral trochlea of rats .Histological and biochemical method were used to evaluate the repairing effect of different material at different points(10 ,20 ,40 d) .Results Repairing effect of group C was best by histological and biochemical method at different points ,followed by group B ,and they were better than that of group A .Conclusion Hyaluronic acid hydrogel could provide cartilage cell proliferation for porous space truss structure ,and could carry cartilage cells at the same time .the cellular space truss structure have high surrounding tissue compatibil‐ity and biodegradation ,it is helpful for cartilage cell survival ,reproduction and division .