CAJ | 학술논문

目的：通过检测不同细菌种属临床感染患者外周血淋巴细胞亚群分布的情况，对患者机体免疫功能的变化进行分析。方法采用流式细胞术对400例健康体检者（对照组）及60例不同细菌感染患者（感染组）体内B细胞、NK细胞、T细胞及其亚群进行检测，并对其结果进行比较分析。结果感染组患者的T4细胞、DN-T细胞、T4/T8比值依次为（28.42±12.24）、（4.85±3.92）和（1.11±0.81），与健康对照组比较，对照组分别为（35.21±5.14）、（6.13±3.06）和（1.41±0.26），感染组低于对照组，感染组的T 8细胞为（31.98±14.08），高于对照组的（25.04±4.32），差异均有统计学意义(P<0.05)。结论细菌感染患者的机体免疫功能存在一定程度的紊乱，并以免疫功能受抑制为主，少部分细菌感染使患者免疫功能增强。
목적：통과검측불동세균충속림상감염환자외주혈림파세포아군분포적정황，대환자궤체면역공능적변화진행분석。방법채용류식세포술대400례건강체검자（대조조）급60례불동세균감염환자（감염조）체내B세포、NK세포、T세포급기아군진행검측，병대기결과진행비교분석。결과감염조환자적T4세포、DN-T세포、T4/T8비치의차위（28.42±12.24）、（4.85±3.92）화（1.11±0.81），여건강대조조비교，대조조분별위（35.21±5.14）、（6.13±3.06）화（1.41±0.26），감염조저우대조조，감염조적T 8세포위（31.98±14.08），고우대조조적（25.04±4.32），차이균유통계학의의(P<0.05)。결론세균감염환자적궤체면역공능존재일정정도적문란，병이면역공능수억제위주，소부분세균감염사환자면역공능증강。
Objective To analyze the change of the body's immune function in patients with clinical infection caused by different bacteria species through testing their distribution of lymphocyte subsets in peripheral blood.Methods 60 patients with different bacterial infections and 400 healthy individuals were enrolled and measured for the levels of B cell,NK cell,T cell and its subgroups in vivo by using a flow cytometry.And the results were compared and analyzed.Results T4 cells, DN-T cells and T4/T8 ratio in the infected patients were successively(28.42±12.24), (4.85±3.92)and(1.11±0.81). Compared with healthy controls, the levels of control group were(35.21±5.14),(6.13±3.06)and(1.41±0.26). So infection group is lower than the control group.T8 cells of the infected group was (31.98±14.08), higher than (25.04 ±4.32) in the control group.All the differences had statistical significance (P<0.05).Conclusion The body's immune function in patients with bacterial infection developed a certain degree of disorder, giving priority to with immune function inhibition but boosting the immune function in patients with some bacteria infection.