CAJ | 학술논문

目的：制备兔腹主动脉粥样斑块模型，并使用超声监测其形成过程。方法使用高脂饲养法对60只日本雄性大白兔进行喂养（模型组，死亡6只），超声监测其腹主动脉粥样斑块形成的过程，并与20只正常兔对照（正常组），最终通过病理证实。结果模型组52只兔腹主动脉粥样斑块模型制备成功，腹主动脉内中膜复合体厚度明显高于正常组。结论高脂饮食是进行兔动脉粥样硬化模型制备的有效方法，动脉粥样硬化以动脉粥样斑块形成为典型特征，高频超声能很好地评价兔腹主动脉粥样斑块形成的过程及情况。
목적：제비토복주동맥죽양반괴모형，병사용초성감측기형성과정。방법사용고지사양법대60지일본웅성대백토진행위양（모형조，사망6지），초성감측기복주동맥죽양반괴형성적과정，병여20지정상토대조（정상조），최종통과병리증실。결과모형조52지토복주동맥죽양반괴모형제비성공，복주동맥내중막복합체후도명현고우정상조。결론고지음식시진행토동맥죽양경화모형제비적유효방법，동맥죽양경화이동맥죽양반괴형성위전형특정，고빈초성능흔호지평개토복주동맥죽양반괴형성적과정급정황。
Objective To prepare the rabbit abdominal aorta atheromatous plaque model ,and to monitor its forming process by ultrasound .Methods Totally 60 Japanese male white rabbits(mdel group ,dead 6 rabbits) fed by high fat diet and the abdominal a‐orta atheromatous plaque formation process was monitored by ultrasound ,20 normal rabbits were taken as control .The abdominal aorta atheromatous plaque was finally confirmed by pathology .Results 52 rabbits in the model group were successful in preparing the abdominal aortic plaque model .The thickness of intima‐media complex was obviously higher than that of the control group .Con‐clusion High fat diet is an effective method for preparing the rabbit atherosclerosis model .The arterial atheromatous plaque forma‐tion is the typical characteristic of atherosclerosis .The high frequency ultrasound can better evaluate the formation process and con‐dition of rabbit abdominal aorta atheromatous plaque .