CAJ | 학술논문

目的：应用妥洛特罗贴剂对5岁以下疑似喘息性疾病的儿童进行诊断性治疗并评价其安全性。方法选取5岁以下疑似喘息性疾病的儿童，按就诊单双日分为试验组和对照组。两组患儿均给予常规治疗（抗感染、止咳化痰、对症支持治疗），试验组加用妥洛特罗贴剂治疗。比较两组病例在治疗后24、72 h 和5 d 这3个时间点日间和夜间咳嗽症状改善情况、起效时间、咳嗽消失时间及不良事件的发生率。结果试验组在3个时间点日间和夜间咳嗽症状缓解总有效率均高于对照组（P ＜0．05）；治疗后两组起效时间在日间差异无统计学意义（P＞0．05），在夜间差异有统计学意义（P＜0．05）；两组咳嗽消失时间比较，差异有统计学意义（P＜0．05），尤以夜间咳嗽消失时间试验组较对照组明显缩短。两组不良事件发生率差异无统计学意义（P ＞0．05）。结论妥洛特罗贴剂经皮给药作为5岁以下喘息性疾病儿童的诊断性治疗方法之一，疗效确切，使用安全方便，患儿依从性高，家属容易接受，明显缩短了治疗疗程，值得推广。
목적：응용타락특라첩제대5세이하의사천식성질병적인동진행진단성치료병평개기안전성。방법선취5세이하의사천식성질병적인동，안취진단쌍일분위시험조화대조조。량조환인균급여상규치료（항감염、지해화담、대증지지치료），시험조가용타락특라첩제치료。비교량조병례재치료후24、72 h 화5 d 저3개시간점일간화야간해수증상개선정황、기효시간、해수소실시간급불량사건적발생솔。결과시험조재3개시간점일간화야간해수증상완해총유효솔균고우대조조（P ＜0．05）；치료후량조기효시간재일간차이무통계학의의（P＞0．05），재야간차이유통계학의의（P＜0．05）；량조해수소실시간비교，차이유통계학의의（P＜0．05），우이야간해수소실시간시험조교대조조명현축단。량조불량사건발생솔차이무통계학의의（P ＞0．05）。결론타락특라첩제경피급약작위5세이하천식성질병인동적진단성치료방법지일，료효학절，사용안전방편，환인의종성고，가속용역접수，명현축단료치료료정，치득추엄。
Objective To conduct the diagnostic treatment in the children under 5 years old with suspected asthmatic disease and to evaluate its safety .Methods The children outpatients with suspected asthmatic diseas were selected and divided into the experi‐mental group and the control group according to odd days and even days .The conventiona therapy of anti‐infection ,relieving cough , reducing sputum and supporting treatment were administered in both groups .The experimental group was added tulobuterol tape . The cough relieve on daytime and nighttime ,initial effective time ,cough disappearance time and occurrence rate of adverse events at 24 ,72 h and on 5 d after treatment were compared between the two groups .Results The total effective rate of cough sysmptom re‐lief in the experimental group at 3 time points and nighttime was higher than that in the control group with statistical difference be‐tween the two groups(P < 0 .05) .The initial effective time had no statistically significant difference in daytime between the two groups(P> 0 .05) ,but which in daytime showed the statistically significant difference (P < 0 .05) ,especially the cough disappear‐ance time at nighttime in the experimental group was significantly shortened than that in the control group( P < 0 .05) .The oc‐curence rate of adverse events had no statistical difference between the two groups(P > 0 .05) .Conclusion Tulobuterol tape by transdermal delivery as one of diagnostic treatment measures for children under 5 years old with suspected asthmatic disease is defi‐nitely effective ,safe and convenient in application with the high compliance for children patients and acceptability by the family members ,obviously shortens the course of treatment ,which is worthy of being promoted .