CAJ | 학술논문

目的：探讨血清组蛋白去乙酰化酶3（HDAC3）、胱抑素 C （CysC）和清蛋白水平对大面积心肌梗死的预测价值。方法急性心肌梗死（AMI）患者102例，按住院期间是否发生心功能不全和／或心源性休克分为两组：不伴心功能不全和／或心源性休克组63例，伴心功能不全和／或心源性休克组39例。再按肌酸激酶同工酶（CK‐MB）峰值是否大于200 IU ／L 分为两组：CK‐MB 峰值大于或等于200 IU ／L 病例组（n＝58）和 CK‐MB 峰值小于200 IU ／L 病例组（n＝44）。所有患者入院第2天清晨检测血清 HDAC3、CysC 和清蛋白水平。结果与未发生心功能不全和／或心源性休克组比较，发生心功能不全和／或心源性休克组的患者血清 HDAC3和 CysC 水平显著升高（P＜0．01），血清清蛋白水平显著降低（P＜0．01）。与 CK‐MB 峰值小于200 IU ／L 病例组患者对比，CK‐MB 峰值大于200 IU ／L 病例组患者的血清 HDAC3和 CysC 水平显著升高（P ＜0．01），血清清蛋白水平显著降低（P＜0．01）。结论血清 HDAC3、CysC 和清蛋白水平对大面积心肌梗死有一定预测价值，有利于判断患者的预后。
목적：탐토혈청조단백거을선화매3（HDAC3）、광억소 C （CysC）화청단백수평대대면적심기경사적예측개치。방법급성심기경사（AMI）환자102례，안주원기간시부발생심공능불전화／혹심원성휴극분위량조：불반심공능불전화／혹심원성휴극조63례，반심공능불전화／혹심원성휴극조39례。재안기산격매동공매（CK‐MB）봉치시부대우200 IU ／L 분위량조：CK‐MB 봉치대우혹등우200 IU ／L 병례조（n＝58）화 CK‐MB 봉치소우200 IU ／L 병례조（n＝44）。소유환자입원제2천청신검측혈청 HDAC3、CysC 화청단백수평。결과여미발생심공능불전화／혹심원성휴극조비교，발생심공능불전화／혹심원성휴극조적환자혈청 HDAC3화 CysC 수평현저승고（P＜0．01），혈청청단백수평현저강저（P＜0．01）。여 CK‐MB 봉치소우200 IU ／L 병례조환자대비，CK‐MB 봉치대우200 IU ／L 병례조환자적혈청 HDAC3화 CysC 수평현저승고（P ＜0．01），혈청청단백수평현저강저（P＜0．01）。결론혈청 HDAC3、CysC 화청단백수평대대면적심기경사유일정예측개치，유리우판단환자적예후。
Objective To investigate the predictive value of serum histone deacetylase 3(HDAC3) ,cystatin C(CysC) and albu‐min levels on a large area of myocardial infarction .Methods According to whether heart failure and (or) cardiogenic shock occur‐ring during hospitalization ,102 patients with acute myocardial infarction(AMI) were divided into the two groups :the non - compli‐cating heart failure and (or) cardiogenic shock group(n= 63) and the complicating heart failure and (or) cardiogenic shock group(n= 39) .Then according to whether the creatine kinase(CK‐MB) peak value was greater than 200 IU /L ,102 AMI patients were di‐vided into two groups :CK‐MB peak values ≥ 200 IU /L group(n= 58) and the CK‐MB peak values < 200 IU / L group(n= 44) .The serum HDAC3 ,CysC and albumin levels were detected at early morning on 2 d of admission in all patients .Results Compared with the non - complicating heart failure and (or) cardiogenic shock group ,serum HDAC3 and CysC levels in the the complicating heart failure and (or) cardiogenic shock group were significantly increased(P< 0 .01) ,while serum albumin protein level was significantly in the occurrence of heart failure and(or)cardiogenic shock group .Compared with the CK‐MB peak value < 200 IU /L group ,serum HDAC3 and CysC levels in the CK‐MB peak value > 200 IU /L group were significantly increased (P< 0 .01) ,while serum albumin level was significantly decreased(P< 0 .01) .Conclusion Serum HDAC3 ,CysC and albumin levels have certain predictive value on a large area of myocardial infarction and conduce to judge the prognosis of patients .