CAJ | 학술논문

目的：研究妊娠高血压综合征（简称妊高征）患者胎儿不同节段脐带血管形态的改变情况，探讨妊高征和脐带血管形态的关系。方法收集胎儿脐带36条，来自健康孕妇17例，妊高征患者19例（轻度子痫前期患者9例，重度子痫前期患者6例，子痫患者4例），取不同节段（胎盘端、中间段、胎儿端）的脐带组织进行常规脱水、包埋、切片及染色。采用数码显微镜进行显微摄像，计算机图像分析软件测试不同节段脐带静脉和动脉血管管径、管壁和管壁／管径比值，并对测试结果进行分析比较。结果从胎盘端到胎儿端，脐带静脉和动脉管径、管壁／管径比值逐渐减小，而管壁逐渐增厚（P＜0．05）。与健康孕妇相比，妊高征患者胎儿的脐带静脉和动脉管径、管径／管壁比值明显减小，管壁明显增厚，并随病情严重程度逐步加剧（P＜0．05）。结论妊高征与脐带血管形态结构变化关系密切，脐静脉的变化明显大于脐动脉，以胎儿端最为明显。
목적：연구임신고혈압종합정（간칭임고정）환자태인불동절단제대혈관형태적개변정황，탐토임고정화제대혈관형태적관계。방법수집태인제대36조，래자건강잉부17례，임고정환자19례（경도자간전기환자9례，중도자간전기환자6례，자간환자4례），취불동절단（태반단、중간단、태인단）적제대조직진행상규탈수、포매、절편급염색。채용수마현미경진행현미섭상，계산궤도상분석연건측시불동절단제대정맥화동맥혈관관경、관벽화관벽／관경비치，병대측시결과진행분석비교。결과종태반단도태인단，제대정맥화동맥관경、관벽／관경비치축점감소，이관벽축점증후（P＜0．05）。여건강잉부상비，임고정환자태인적제대정맥화동맥관경、관경／관벽비치명현감소，관벽명현증후，병수병정엄중정도축보가극（P＜0．05）。결론임고정여제대혈관형태결구변화관계밀절，제정맥적변화명현대우제동맥，이태인단최위명현。
Objective To study morphological structural changes for different segment umbilical vessels of fetus in patients with pregnancy induced hypertension (PIH) ,and explore relationship between PIH and umbilical vessels .Methods Totally 36 umbilical cords from fetus of pregnant women without and with PIH (17 cases ,19 controls) were collected ,and take umbilical cord of placen‐tal ,middle ,and fetal segment to routine dehydration ,embedding ,section and stain .In the cases 9 women had mild preeclampsia ,6 had severe preeclampsia and 4 had eclampsia .Microscope images were obtained by digital microscope ,and lumen diameter ,wall thickness and wall‐luminal ratio of different segment umbilical vein and arteries were tested by computer image analysis software . The test results were analyzed and compared .Results From the placental end to the fetal end ,the lumen diameter and wall‐luminal ratio gradually decreased ,and wall thickness gradually increased in the umbilical vein and arteries (P<0 .05) .Compared to normal pregnant women ,the lumen diameter and wall‐luminal ratio decreased ,and wall thickness increased in patients with PIH ,and the a‐bove changes aggravated by disease severity (P<0 .05) .Conclusion PIH is associated with structural changes in the umbilical ves‐sels .These changes are more predominant in the vein than in the artery and most obvious in the fetal end .