数理医药学杂志
數理醫藥學雜誌
수리의약학잡지
JOURNAL OF MATHEMATICAL MEDICINE
2015年
1期
70-71,72
,共3页
Graves’眼病%西乐葆%前列腺素E2%白细胞介素-1%眼病指数
Graves’眼病%西樂葆%前列腺素E2%白細胞介素-1%眼病指數
Graves’안병%서악보%전렬선소E2%백세포개소-1%안병지수
graves’ophthalmopathy%celebrex%prostaglandin E2%interleukin-1%ophthalmopathy index
目的:分析西乐葆治疗Graves’眼病(Graves’ophthalmopathy,GO)的近期疗效。方法:取Graves’眼病(GO)患者30例52只眼做为研究对象。环氧酶2(COX-2)抑制剂西乐葆(Celebrex)治疗3个月。观察和记录治疗前后其泪液前列腺素E2(PGE2)、血清白细胞介素-1(IL-1)水平以及眼病指数ophthalmopathy index(OI),并进行统计学分析。结果:治疗后泪液PGE2、血清IL-1水平均较治疗前有明显下降,差异显著(P<0.01),眼病指数OI有明显改善,差异有统计学意义(P<0.05)。结论:早期西乐葆治疗降低了泪液PGE2和血液IL-1的浓度,对改善Graves’眼病有一定效果。
目的:分析西樂葆治療Graves’眼病(Graves’ophthalmopathy,GO)的近期療效。方法:取Graves’眼病(GO)患者30例52隻眼做為研究對象。環氧酶2(COX-2)抑製劑西樂葆(Celebrex)治療3箇月。觀察和記錄治療前後其淚液前列腺素E2(PGE2)、血清白細胞介素-1(IL-1)水平以及眼病指數ophthalmopathy index(OI),併進行統計學分析。結果:治療後淚液PGE2、血清IL-1水平均較治療前有明顯下降,差異顯著(P<0.01),眼病指數OI有明顯改善,差異有統計學意義(P<0.05)。結論:早期西樂葆治療降低瞭淚液PGE2和血液IL-1的濃度,對改善Graves’眼病有一定效果。
목적:분석서악보치료Graves’안병(Graves’ophthalmopathy,GO)적근기료효。방법:취Graves’안병(GO)환자30례52지안주위연구대상。배양매2(COX-2)억제제서악보(Celebrex)치료3개월。관찰화기록치료전후기루액전렬선소E2(PGE2)、혈청백세포개소-1(IL-1)수평이급안병지수ophthalmopathy index(OI),병진행통계학분석。결과:치료후루액PGE2、혈청IL-1수평균교치료전유명현하강,차이현저(P<0.01),안병지수OI유명현개선,차이유통계학의의(P<0.05)。결론:조기서악보치료강저료루액PGE2화혈액IL-1적농도,대개선Graves’안병유일정효과。
Objective: To analyze the short-term clinical efficacy of Celebrextherapy in Graves ophthalmopa-thy. Methods: The fifty-two eyes of 30 patients with Graves’ophthalmopathy were chosen for the treatment with Celebrex (selective COX-2 inhibitor) for 3 months. The tear PGE2, plasma IL-1, and ophthalmopathy index(OI) were measured before and after treatment.Results: After Celebrex treatment, the levels of the tear PGE2 and plasma IL1 were decreased significantly(P<0.01),while the ophthalmopathy index was improved obviously(P<0.05).No com- <br> plication was found. Conclusion: Celebrex therapy for Graves’ophthalmopathy is safe and effective,can be used as the preferred treatment In the early stages.