CAJ | 학술논문

目的：明确兰索拉唑临床应用和不良反应，为药物的应用范围及其安全性问题提供文献依据和研究思路。方法对近十几年来兰索拉唑国内外相关临床药理作用和不良反应报道进行整理、归纳与分析。结果兰索拉唑常用于十二指肠溃疡、胃溃疡、反流性食管炎、卓-艾综合征等各种消化功能紊乱性疾病，其疗效高，不良反应少。结论建议在临床应用兰索拉唑时，应严格按照药品说明书和相关指南，对症用药，控制用药剂量与疗程，减少药品不良反应发生，注重联合用药尤其是中西药物联合用药的指征、用法、用量、疗程的研究，提高用药合理性和有效性。
목적：명학란색랍서림상응용화불량반응，위약물적응용범위급기안전성문제제공문헌의거화연구사로。방법대근십궤년래란색랍서국내외상관림상약리작용화불량반응보도진행정리、귀납여분석。결과란색랍서상용우십이지장궤양、위궤양、반류성식관염、탁-애종합정등각충소화공능문란성질병，기료효고，불량반응소。결론건의재림상응용란색랍서시，응엄격안조약품설명서화상관지남，대증용약，공제용약제량여료정，감소약품불량반응발생，주중연합용약우기시중서약물연합용약적지정、용법、용량、료정적연구，제고용약합이성화유효성。
Objective To explore the clinical applications and adverse reactions of lansoprazole and provide literature basis and idea for the application range and safety issues of lansoprazole. Methods References in the last decades at home and abroad about the clinical pharmacological actions and adverse reactions of lansoprazole were collated, analyzed and summarized. Results Lansoprazole is always used to treat the diseases of duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other digestive function disorder diseases. Compared with other proton-pump inhibitors, lansoprazole has the advantages of higher curative effect and less adverse reactions. Conclusion We'd better be in accordance with the drug instructions or under the guidance of pharmacist when lansoprazole has to be used for the corresponding disease. The dosages and treatment course should be controlled to reduce adverse reactions. At the same time, the researches of indication, usage, dosage and treatment course of lansoprazole combined with Chinese herbs and/or western medicine should be paid more attention to improve its rationality and effectiveness.