CAJ | 학술논문

目的：探讨利妥昔单抗联合 CHOP 方案（R-CHOP）治疗非霍奇金淋巴瘤合并非活动性 HBsAg 携带者的治疗方法。方法报道1例行 R-CHOP 方案治疗非霍奇金淋巴瘤合并非活动性 HBsAg 携带者患者，未行抗病毒治疗的疾病进程，并复习近年来国内外发表的相关文献。结果本例患者应用 R-CHOP 方案化疗前未行抗病毒治疗，引起HBV 再激活，致肝功能衰竭。结论应明确抗病毒治疗对防止非霍奇金淋巴瘤患者化疗过程中 HBV 再激活的重要性。
목적：탐토리타석단항연합 CHOP 방안（R-CHOP）치료비곽기금림파류합병비활동성 HBsAg 휴대자적치료방법。방법보도1례행 R-CHOP 방안치료비곽기금림파류합병비활동성 HBsAg 휴대자환자，미행항병독치료적질병진정，병복습근년래국내외발표적상관문헌。결과본례환자응용 R-CHOP 방안화료전미행항병독치료，인기HBV 재격활，치간공능쇠갈。결론응명학항병독치료대방지비곽기금림파류환자화료과정중 HBV 재격활적중요성。
Objective To review the role of antiviral therapy among inactive HBsAg carriers with non-Hodgkin′s lymphoma (NHL)treated with rituximab in combination with CHOP chemotherapy (R-CHOP).Methods We reported an inactive HBsAg carrier with NHL who was treated with R-CHOP and developed liver failure,and the relevant literatures were reviewed.Results Lacking prnor-antiviral therapytreatment for hepatitis B virus infection before R-CHOP,which increased the risk of hepatitis flare-up in inactive HBsAg carriers with NHL,might cause damage to the liver and even eventually lead to full-blown liver failure.Conclusion Antiviral treatment for hepatitis B virus infection in inactive HBsAg carriers with NHL should be paid more attention.