CAJ | 학술논문

目的：探讨阿立哌唑治疗精神分裂症阴性症状的疗效和安全性。方法80名精神分裂症患者随机分为研究组（阿立哌唑治疗）和对照组（利培酮治疗），每组40例，在治疗前及治疗的2、4、8周末分别采用潘氏阳性与阴性症状量表（PANSS）、阴性症状评定量表（SANS）评分，并记录治疗期间发生的不良反应。结果两组患者治疗后的 PANSS 量表总分及 SANS 总分均明显降低（P ＜0.05），但同一时期，两组患者间的 PANSS 量表总分及 SANS 量表评分差异无统计学意义（P ＞0.05）。在治疗后第4、8周，研究组患者“思维贫乏”及“意志缺乏”的因子分较对照组明显下降（P ＜0.05），而对照组患者“兴趣／社交缺乏”的评分则明显低于同期的研究组患者（P ＜0.05）。阿立哌唑不良反应发生率小于利培酮（P ＜0.05）。结论阿立哌唑与利培酮均能改善精神分裂症患者的阴性症状，且总体疗效相似，但阿立哌唑更善于改善患者的情感与认知症状，而利培酮则对患者的情感与行为症状更有效。阿立哌唑的用药安全性总体上优于利培酮。
목적：탐토아립고서치료정신분렬증음성증상적료효화안전성。방법80명정신분렬증환자수궤분위연구조（아립고서치료）화대조조（리배동치료），매조40례，재치료전급치료적2、4、8주말분별채용반씨양성여음성증상량표（PANSS）、음성증상평정량표（SANS）평분，병기록치료기간발생적불량반응。결과량조환자치료후적 PANSS 량표총분급 SANS 총분균명현강저（P ＜0.05），단동일시기，량조환자간적 PANSS 량표총분급 SANS 량표평분차이무통계학의의（P ＞0.05）。재치료후제4、8주，연구조환자“사유빈핍”급“의지결핍”적인자분교대조조명현하강（P ＜0.05），이대조조환자“흥취／사교결핍”적평분칙명현저우동기적연구조환자（P ＜0.05）。아립고서불량반응발생솔소우리배동（P ＜0.05）。결론아립고서여리배동균능개선정신분렬증환자적음성증상，차총체료효상사，단아립고서경선우개선환자적정감여인지증상，이리배동칙대환자적정감여행위증상경유효。아립고서적용약안전성총체상우우리배동。
Objective To explore the efficacy and safety of aripiprazole in treating negtive symptoms of schizophrenia.Methods Eighty patients with schizophrenia were randomly assigned to the experimental group(treated with aripiprazole)and the control group(treated with risperidone),with 40 cases in each group.Positive and Negative Syndrome Scale(PANSS)and Scale for Assessment of Negative Symptoms(SANS)were used before treatment,and at the weekend of 2nd,4th,8th after treatment respectively.Results The scores of PANSS and SANS in both groups were decreased in comparison with those pretreatment(P <0.05),but there was no significant difference between the two groups(P >0.05).At the 4th,8th weekends of post-treatment,the scores of“poverty of thought”and“abulia”in experimental group were decreased in comparison with those in the control group(P <0.05),while the score of“lack of social or interest”was higher than that in the control group(P >0.05).The incidence of adverse effect in experimental group was less than that in the control group(P <0.05).Conclusion Both aripiprazole and risperidone can improve the negative symptoms of schizophrenia with the similar efficacy;however,aripi-prazole is adept in treating the symptoms of affection and cognition,compared with the advantage of risperidone in treating the symptoms of af-fection and behavior.Aripiprazole is generally safer than risperidone.