安徽医学
安徽醫學
안휘의학
ANHUI MEDICAL JOURNAL
2014年
12期
1690-1692,1693
,共4页
养血清脑颗粒%胞二磷胆碱%脑卒中%认知功能障碍%神经心理测评
養血清腦顆粒%胞二燐膽堿%腦卒中%認知功能障礙%神經心理測評
양혈청뇌과립%포이린담감%뇌졸중%인지공능장애%신경심리측평
Yangxueqingnao granule%Citicoline%Cerebral apoplexy%Cognitive impairment%Neuropsychological evaluation
目的：观察并探讨养血清脑颗粒联合胞二磷胆碱对轻度血管性认知障碍的临床疗效。方法选取轻度血管性认知障碍的患者104例，联合应用养血清脑颗粒与胞二磷胆碱进行治疗，治疗前后对患者进行神经心理测评（MMSE、ADAS-Cog、Mo-CA 评分），以评价临床疗效。结果治疗结束后，患者 MMSE 评分比较差异无统计学意义（P ＞0.05），MoCA 评分显著高于治疗前（P ＜0.05），ADAS-Cog 评分均显著低于治疗前（P ＜0.05）。MoCA 量表中，患者治疗后在视空间与执行能力、记忆、语言、延迟回忆等方面得分显著高于治疗前（P ＜0.05）。ADAS-Cog 量表中，患者治疗后在单词回忆、单词辨认、回忆测验指令、口语能力、找词困难、语言理解能力等方面得分显著低于治疗前（P ＜0.05）。结论养血清脑颗粒联合胞二磷胆碱给药可显著改善患者认知功能障碍状态，尤其是在患者记忆、延迟回忆测试、执行功能、语言运用等方面的改善效果较好。
目的：觀察併探討養血清腦顆粒聯閤胞二燐膽堿對輕度血管性認知障礙的臨床療效。方法選取輕度血管性認知障礙的患者104例，聯閤應用養血清腦顆粒與胞二燐膽堿進行治療，治療前後對患者進行神經心理測評（MMSE、ADAS-Cog、Mo-CA 評分），以評價臨床療效。結果治療結束後，患者 MMSE 評分比較差異無統計學意義（P ＞0.05），MoCA 評分顯著高于治療前（P ＜0.05），ADAS-Cog 評分均顯著低于治療前（P ＜0.05）。MoCA 量錶中，患者治療後在視空間與執行能力、記憶、語言、延遲迴憶等方麵得分顯著高于治療前（P ＜0.05）。ADAS-Cog 量錶中，患者治療後在單詞迴憶、單詞辨認、迴憶測驗指令、口語能力、找詞睏難、語言理解能力等方麵得分顯著低于治療前（P ＜0.05）。結論養血清腦顆粒聯閤胞二燐膽堿給藥可顯著改善患者認知功能障礙狀態，尤其是在患者記憶、延遲迴憶測試、執行功能、語言運用等方麵的改善效果較好。
목적：관찰병탐토양혈청뇌과립연합포이린담감대경도혈관성인지장애적림상료효。방법선취경도혈관성인지장애적환자104례，연합응용양혈청뇌과립여포이린담감진행치료，치료전후대환자진행신경심리측평（MMSE、ADAS-Cog、Mo-CA 평분），이평개림상료효。결과치료결속후，환자 MMSE 평분비교차이무통계학의의（P ＞0.05），MoCA 평분현저고우치료전（P ＜0.05），ADAS-Cog 평분균현저저우치료전（P ＜0.05）。MoCA 량표중，환자치료후재시공간여집행능력、기억、어언、연지회억등방면득분현저고우치료전（P ＜0.05）。ADAS-Cog 량표중，환자치료후재단사회억、단사변인、회억측험지령、구어능력、조사곤난、어언리해능력등방면득분현저저우치료전（P ＜0.05）。결론양혈청뇌과립연합포이린담감급약가현저개선환자인지공능장애상태，우기시재환자기억、연지회억측시、집행공능、어언운용등방면적개선효과교호。
Objective To observe and discuss the clinical efficacy of Yangxueqingnao granule plus citcoline on patients with mild vascular cognitive impairment.Methods A total of 104 cases with mild vascular cognitive impairment were selected as study objects and were applied with Yangxueqingnao granule and citicoline tablet for 3 months,after which MMSE,ADAS-Cog,MoCA score was introduced into neuropsychological evaluation on patients;meanwhile,patientsclinical safety was observed.Results There was no significant difference in MMSE score between post and pretreatment(P >0.05),MoCA score after treatment was significantly higher than that of pretreatment(P <0.05),and ADAS-Cog score was significantly lower than that of pretreatment(P <0.05).During MoCA evaluation,visual spatial &executive ability,memory,language,delayed memory scores of patients after treatment were significantly higher than those before treatment (P <0.05).During ADAS-Cog evaluation,word recall,word recognition,recall test instruction,oral language,word finding difficulties,language compre-hension ability scores of patients after treatment were significantly lower than those before treatment(P <0.05).Conclusion Yangxueqing-nao granule combined with citicoline tablet can significantly improve the cognitive function of patients with mild vascular cognitive impair-ment,especially works well in memory,delayed recall test,executive function,language and other aspects.
