CAJ | 학술논문

目的：研究利拉鲁肽治疗2型糖尿病（T2DM）的临床疗效。方法选取2012年9月至2014年3月入院的初诊T2DM患者86例，随机分为对照组和试验组。对照组患者接受常规药物治疗，试验组患者接受利拉鲁肽进行治疗，期间监测血糖并调整用药剂量，治疗3个月后比较两组患者的糖化血红蛋白、空腹血糖、餐后2 h 血糖、体质量等指标的变化。结果对比治疗前，两组治疗后的检测指标都有显著降低，但试验组比对照组降低更为明显，差异有统计学意义（P ＜0.05），而且试验组患者出现不良反应率明显低于对照组。结论利拉鲁肽对 T2DM的治疗具有很好的疗效和安全性，应该在临床上予以推广。
목적：연구리랍로태치료2형당뇨병（T2DM）적림상료효。방법선취2012년9월지2014년3월입원적초진T2DM환자86례，수궤분위대조조화시험조。대조조환자접수상규약물치료，시험조환자접수리랍로태진행치료，기간감측혈당병조정용약제량，치료3개월후비교량조환자적당화혈홍단백、공복혈당、찬후2 h 혈당、체질량등지표적변화。결과대비치료전，량조치료후적검측지표도유현저강저，단시험조비대조조강저경위명현，차이유통계학의의（P ＜0.05），이차시험조환자출현불량반응솔명현저우대조조。결론리랍로태대 T2DM적치료구유흔호적료효화안전성，응해재림상상여이추엄。
Objective To investigate the clinical therapeutic effects of liraglutide on type 2 diabetes(T2DM).Methods Eighty-six patients with newly diagnosed type 2 diabetes in our hospital from Sep.2012 to Apr.2014 were randomly divided into control group and exper-imental group.Patients in the control group were treated with conventional drugs,and those in the experimental group were treated with lira-glutide.Their glucose was monitored and the dose adjusted as needed.Three months later,the HbA1c,FPG,2 hPBG,BMI,TG and TC of the wo groups were compared.Results Compared with before treatment,the indexes were significantly reduced after treatment,the experimental group was more apparent than the control group,and the difference was statistically significant(P <0.05).Besides,the adverse reaction rate of experimental group were significantly lower than that of control group.Conclusion Liraglutide in the treatment of type 2 diabetes has a good efficacy and safety,which should be promoted in clinical application.