CAJ | 학술논문

目的：探讨弥散加权成像（DWI）联合甲胎蛋白（AFP）对原发性肝癌（PHC）早期诊断价值。方法回顾分析34例经手术或穿刺活检病理证实为肝癌患者的临床资料，患者均行放射免疫法检测血清 AFP 并行 MRI 常规扫描及 DWI 序列扫描。结果AFP、DWI 联合 AFP 诊断 PHC 的敏感度、特异度、阳性预测值、假阳性率、阴性预测值及假阴性率分别是：AFP（200 ng／L）为37.50％，100.00％，100.00％，0.00％，9.09％和62.50％；AFP （400 ng／L）为31.25％，100.00％，100.00％，0.00％，8.33％和68.75％；DWI 联合 AFP （200 ng／L）为78.13％，50.00％，96.15％，20.00％，12.50％和21.88％；DWI 联合 AFP （400 ng／L）为71.86％，50.00％，96.15％，20.00％，10.00％和28.13％。结论DWI 联合甲胎蛋白可以提高 PHC 诊断率，为 PHC 的早期诊断提供了有效依据。
목적：탐토미산가권성상（DWI）연합갑태단백（AFP）대원발성간암（PHC）조기진단개치。방법회고분석34례경수술혹천자활검병리증실위간암환자적림상자료，환자균행방사면역법검측혈청 AFP 병행 MRI 상규소묘급 DWI 서렬소묘。결과AFP、DWI 연합 AFP 진단 PHC 적민감도、특이도、양성예측치、가양성솔、음성예측치급가음성솔분별시：AFP（200 ng／L）위37.50％，100.00％，100.00％，0.00％，9.09％화62.50％；AFP （400 ng／L）위31.25％，100.00％，100.00％，0.00％，8.33％화68.75％；DWI 연합 AFP （200 ng／L）위78.13％，50.00％，96.15％，20.00％，12.50％화21.88％；DWI 연합 AFP （400 ng／L）위71.86％，50.00％，96.15％，20.00％，10.00％화28.13％。결론DWI 연합갑태단백가이제고 PHC 진단솔，위 PHC 적조기진단제공료유효의거。
Objective To study the value of DWI combined with AFP in the early diagnosis of primary hepatic cancer.Methods The clinical data of 34 cases of postoperative metastasis or recurrence of primary hepatic cancer confirmed by surgery or puncture biopsy were retrospectively analyzed.All the patients underwent the radioimmunoassay detection of serum alpha fetoprotein(AFP)level and DWI.Results In the 34 cases,the sensitivity,specificity,positive predictive value and negative predictive value for AFP(200 ng/L)was 37.50%,100.00%,100.00%,0.00%,9.09%,and 62.50%,respectively;for AFP (400 ng/L)was 31.25%,100.00%,100.00%, 0.00%,8.33%,and 68.75%,respectively;for DWI +AFP(200 ng/L)was 78.13%,50.00%,96.15%,20.00%,12.50%,and 21.88%, respectively;for DWI +AFP(400 ng/L)was 71.86%,50.00%,96.15%,20.00%,10.00%,and 28.13%,respectively.Conclusion DWI combined with AFP is sensitive to primary hepatic cancer,and it provides effective basis for the early diagnosis of primary hepatic cancer.