CAJ | 학술논문

目的：研究脓毒症大鼠早期血清中炎性因子与心肌损伤之间的相关性。方法72只雌性清洁级 SD 大鼠随机分为假手术组（n ＝36）和脓毒症组（n ＝36），分别行盲肠探查术、盲肠结扎穿孔术，均于术后3、9、24、36、48和72 h 采腹主动脉血检测肌钙蛋白 I（cTnI）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）水平。结果TNF-α、IL-1于3 h 达峰值，后逐渐降低，均高于假手术组（P ＜0.05）；cTnI 于3 h 达峰值，后逐渐降低，均高于假手术组（P ＜0.05）；血清 TNF-α、IL-1均与 cTnI 呈显著正相关。结论脓毒症早期炎症因子的升高与心肌损伤具有正相关性，可作为检测和诊断早期脓毒症心肌损伤的重要指标。
목적：연구농독증대서조기혈청중염성인자여심기손상지간적상관성。방법72지자성청길급 SD 대서수궤분위가수술조（n ＝36）화농독증조（n ＝36），분별행맹장탐사술、맹장결찰천공술，균우술후3、9、24、36、48화72 h 채복주동맥혈검측기개단백 I（cTnI）、종류배사인자-α（TNF-α）、백세포개소-1（IL-1）수평。결과TNF-α、IL-1우3 h 체봉치，후축점강저，균고우가수술조（P ＜0.05）；cTnI 우3 h 체봉치，후축점강저，균고우가수술조（P ＜0.05）；혈청 TNF-α、IL-1균여 cTnI 정현저정상관。결론농독증조기염증인자적승고여심기손상구유정상관성，가작위검측화진단조기농독증심기손상적중요지표。
Objective To study the correlation between inflammatory cytokines of serum and myocardial injury in the early stages of septic rats.Methods Seventy-two female clean SD rats were divided into sham operation group(n =36)and sepsis group(n =36)random-ly,and the two groups were performed exploratory surgery and cecum ligation and puncture(CLP)separately.Each group was taken to measure the serum levels of TNF-αand cTnI through abdominal aortic blood at 3,9,24,36,48 and 72 h.Results The level of serum TNF-αand IL-1 peaked at 3 h,then gradually decreased,which were still significantly higher than those of sham operation group(P <0.05);the level of ser-um of cTnI peaked at 3 h,then gradually decreased,which were still significantly higher than those of sham operation group(P <0.05);the levels of serum IL-1 and TNF-α had a significant positive correlation with the serum levels of cTnI in the early stage of sepsis.Conclusion The elevated serum levels of inflammatory cytokines have a positive correlation with myocardial injury in the early stages of sep-sis.This can be used as an important indicator of early sepsis detection and diagnosis of myocardial injury.