CAJ | 학술논문

目的：应用静息态功能磁共振成像（rs-fMRI）探讨广泛性焦虑症（GAD）患者脑静息态局部一致性异常。方法：24例 GAD 患者及24例年龄、性别及教育程度相匹配的健康志愿者行 rs-fMRI，应用基于体素的局部一致性（ReHo）分析法，比较两组中脑 rs-fMRI 的差异（t 检验），并对差异脑区的 ReHo 值与焦虑自评量表（SAS）和汉密尔顿焦虑量表（HAMA）评分进行相关性分析。结果：与对照组比较，GAD 组中 ReHo 值降低的脑区有右侧丘脑、右侧枕中回、左侧额中回和右侧梭状回，ReHo 值增高的脑区有右侧额下回、右侧楔前叶、右侧中央前回、左侧额中回和左侧额上回（P ＜0．001、簇大小＞10个体素）。GAD 组中仅右侧丘脑的 ReHo 值与 HAMA 评分呈显著负相关（γ＝－0．637，P ＝0．001）。结论：rs-fMRI 可以反映 GAD 患者脑功能区的局部一致性改变。
목적：응용정식태공능자공진성상（rs-fMRI）탐토엄범성초필증（GAD）환자뇌정식태국부일치성이상。방법：24례 GAD 환자급24례년령、성별급교육정도상필배적건강지원자행 rs-fMRI，응용기우체소적국부일치성（ReHo）분석법，비교량조중뇌 rs-fMRI 적차이（t 검험），병대차이뇌구적 ReHo 치여초필자평량표（SAS）화한밀이돈초필량표（HAMA）평분진행상관성분석。결과：여대조조비교，GAD 조중 ReHo 치강저적뇌구유우측구뇌、우측침중회、좌측액중회화우측사상회，ReHo 치증고적뇌구유우측액하회、우측설전협、우측중앙전회、좌측액중회화좌측액상회（P ＜0．001、족대소＞10개체소）。GAD 조중부우측구뇌적 ReHo 치여 HAMA 평분정현저부상관（γ＝－0．637，P ＝0．001）。결론：rs-fMRI 가이반영 GAD 환자뇌공능구적국부일치성개변。
Objectire:To investigate regional homogeneity (ReHo)of brain in patients with generalized anxiety disor-der (GAD)using resting-state functional MRI (rs-fMRI).Methods:24 patients with GAD and 24 age-,gender-,and educa-tion-matched healthy volunteers (control group)were included and all of them underwent rs-fMRI.The rs-fMRI data were analyzed with the regional homogeneity method after data conversion.The raw ReHo values were subjected to t-test of voxel wised comparison to derive the resting-state brain function differences between the two groups.The correlation between Re-Ho values of abnormal regions found in GAD group and the scores obtained according to the Self-Rating Anxiety Scale (SAS)and Hamilton Anxiety Scale (HAMA)was analyzed.Results:Compared with the control group,the GAD group showed significantly decreased ReHo value in the right thalamus,right middle occipital gyrus,left middle frontal gyrus,right fusiform gyrus,and increased ReHo value in the right inferior frontal gyrus,right precuneus,right precentral gyrus,left middle frontal gyrus and left superior frontal gyrus (P <0.001,cluster size>10 voxels).The ReHo value of right thalamus in GAD group had a negative correlation with HAMA score (γ=-0.637,P =0.001).Conclusion:Resting-state fMRI with ReHo method can reflect the abnormal brain activity in the patients with generalized anxiety disorder.