中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
24期
1582-1586
,共5页
陈立美%张丽娜%张艳琦%顾林
陳立美%張麗娜%張豔琦%顧林
진립미%장려나%장염기%고림
乳腺肿物%纤维腺瘤%癌变%预后
乳腺腫物%纖維腺瘤%癌變%預後
유선종물%섬유선류%암변%예후
breast neoplasm%fibroadenoma%carcinomatous change%prognosis
目的：探讨乳腺纤维腺瘤癌变（carcinomatous change of the fibroadenoma，CCFA）的临床病理表现、诊疗及预后。方法：对18例CCFA的患者进行一般情况、彩色多普勒超声、乳腺X线钼钯摄影、术后病理及预后分析。选取纤维腺瘤（fibroadenoma， FA）患者超声检查资料24例、乳腺X线钼钯摄影资料20例，分别与CCFA患者超声检查12例、乳腺X线钼钯摄影10例进行对比分析。结果：超声检查显示乳腺纤维腺瘤癌变组与FA组在内部回声、形态、边界及包膜方面存在显著性差异（P<0.05），乳腺X线钼钯摄影显示CCFA组与FA组在边缘情况及是否存在细小密集钙化方面存在显著性差异（P<0.05），而在肿块的形态、是否存在粗颗粒钙化方面无显著性差异（P>0.05）。CCFA 发病多为早期，腋窝淋巴结转移率低。CCFA 患者5年 DFS 和 OS 均为91.67%（11/12）。单因素生存分析中仅腋窝淋巴结转移具有统计学意义，有转移者预后差（P=0.0003）。结论：超声检查及乳腺X线钼钯摄影在鉴别CCFA及FA方面有一定价值。CCFA患者5年生存率较高，预后较好。
目的：探討乳腺纖維腺瘤癌變（carcinomatous change of the fibroadenoma，CCFA）的臨床病理錶現、診療及預後。方法：對18例CCFA的患者進行一般情況、綵色多普勒超聲、乳腺X線鉬鈀攝影、術後病理及預後分析。選取纖維腺瘤（fibroadenoma， FA）患者超聲檢查資料24例、乳腺X線鉬鈀攝影資料20例，分彆與CCFA患者超聲檢查12例、乳腺X線鉬鈀攝影10例進行對比分析。結果：超聲檢查顯示乳腺纖維腺瘤癌變組與FA組在內部迴聲、形態、邊界及包膜方麵存在顯著性差異（P<0.05），乳腺X線鉬鈀攝影顯示CCFA組與FA組在邊緣情況及是否存在細小密集鈣化方麵存在顯著性差異（P<0.05），而在腫塊的形態、是否存在粗顆粒鈣化方麵無顯著性差異（P>0.05）。CCFA 髮病多為早期，腋窩淋巴結轉移率低。CCFA 患者5年 DFS 和 OS 均為91.67%（11/12）。單因素生存分析中僅腋窩淋巴結轉移具有統計學意義，有轉移者預後差（P=0.0003）。結論：超聲檢查及乳腺X線鉬鈀攝影在鑒彆CCFA及FA方麵有一定價值。CCFA患者5年生存率較高，預後較好。
목적：탐토유선섬유선류암변（carcinomatous change of the fibroadenoma，CCFA）적림상병리표현、진료급예후。방법：대18례CCFA적환자진행일반정황、채색다보륵초성、유선X선목파섭영、술후병리급예후분석。선취섬유선류（fibroadenoma， FA）환자초성검사자료24례、유선X선목파섭영자료20례，분별여CCFA환자초성검사12례、유선X선목파섭영10례진행대비분석。결과：초성검사현시유선섬유선류암변조여FA조재내부회성、형태、변계급포막방면존재현저성차이（P<0.05），유선X선목파섭영현시CCFA조여FA조재변연정황급시부존재세소밀집개화방면존재현저성차이（P<0.05），이재종괴적형태、시부존재조과립개화방면무현저성차이（P>0.05）。CCFA 발병다위조기，액와림파결전이솔저。CCFA 환자5년 DFS 화 OS 균위91.67%（11/12）。단인소생존분석중부액와림파결전이구유통계학의의，유전이자예후차（P=0.0003）。결론：초성검사급유선X선목파섭영재감별CCFA급FA방면유일정개치。CCFA환자5년생존솔교고，예후교호。
Objective: To determine clinicopathologic features, diagnosis, treatment, and prognosis of patients with carcinomatous change of fibroadenoma (CCFA). Methods: Clinical and mammographic features, ultrasound, and prognostic and pathological results of 18 patients with CCFA were analyzed. The ultrasound data of 24 cases and mammographic data of 20 cases, which were confirmed by pathological diagnosis, were selected. Imaging data of CCFA (12 cases with ultrasound and 10 with molybdenum data) were also compared. Results: Ultrasound data showed a significant difference in the internal echo, shape, border, and peplos between the groups with CCFA and FA (P<0.05). The mammographic results showed a significant difference (P<0.05) in the border and the existence of small dense calcification between the two groups. However, no significant differences were observed in the shape and coarse calcification between the two groups (P>0.05). CCFA was detected in the early stage, and the rate of axillary lymph node metastasis was low. The five-year DFS and OS was 91.67% in CCFA cases (11/12). The univariate analysis showed that the axillary lymph node metastasis of CCFA cases was statistically significant (P=0.000 3). An unfavorable prognosis in the cases with lymph node metastasis was further detected. Conclusion: Two-dimensional ultrasound and mammography are important in differentiating CCFA and FA. CCFA has a high five-year survival rate with favorable prognosis.
