CAJ | 학술논문

目的：探讨泮托拉唑联合云南白药在心血管疾病高危患者急性非静脉曲张性上消化道出血止血后恢复服用阿司匹林预防再出血及改善内镜评分的疗效和效果。方法收治服用阿司匹林预防心血管疾病致急性非静脉曲张性上消化道出血患者126例，根据年龄、性别、内镜表现分层，按区组随机化方法分成十二指肠溃疡组（治疗组42例，对照组41例）和胃溃疡组（治疗组22例，对照组21例）。各组在应用泮托拉唑治疗止血后恢复服用阿司匹林，对照组用泮托拉唑40 mg静滴，1次/12 h，治疗组用同量泮托拉唑联合云南白药口服，0.5 g/次，4次/d，比较十二指肠溃疡组和胃溃疡组再出血情况及内镜表现。结果泮托拉唑联合云南白药在降低再出血率方面比较，差异无统计学意义；但改善了十二指肠溃疡病例组的内镜评分，差异有统计学意义（P＜0.05）。结论泮托拉唑联合云南白药对改善恢复服用阿司匹林后消化性溃疡的内镜表现优于单用泮托拉唑。
목적：탐토반탁랍서연합운남백약재심혈관질병고위환자급성비정맥곡장성상소화도출혈지혈후회복복용아사필림예방재출혈급개선내경평분적료효화효과。방법수치복용아사필림예방심혈관질병치급성비정맥곡장성상소화도출혈환자126례，근거년령、성별、내경표현분층，안구조수궤화방법분성십이지장궤양조（치료조42례，대조조41례）화위궤양조（치료조22례，대조조21례）。각조재응용반탁랍서치료지혈후회복복용아사필림，대조조용반탁랍서40 mg정적，1차/12 h，치료조용동량반탁랍서연합운남백약구복，0.5 g/차，4차/d，비교십이지장궤양조화위궤양조재출혈정황급내경표현。결과반탁랍서연합운남백약재강저재출혈솔방면비교，차이무통계학의의；단개선료십이지장궤양병례조적내경평분，차이유통계학의의（P＜0.05）。결론반탁랍서연합운남백약대개선회복복용아사필림후소화성궤양적내경표현우우단용반탁랍서。
Objective To search Rehaemorrhagia rate and expression improvement by endoscopy after pantoprazole combination with Yunnan Baiyao in patients re-taking aspirin after nonvariceal upper gastrointestinal bleeding (NVUGIB) hemostasis for their cardiovascular disease(CVD). Methods 126 patients were randomly to receive pantoprazole 80 mg/d(41 duodenal ulcers and 21 gastric ulcers) or pantoprazole 80 mg/d combined with Yunnan Baiyao 2 g/d (42 duodenal ulcers and 22 gastric ulcers),The difference of the Rehaemorrhagia rate and expression improvement by endoscopy were compared. Results There were significantly more expression improvement among combination drugs than among the patients receive pantoprazole in duodenal ulcers group (P<0.05),while not in Rehaemorrhagia rate among the patients receiving pantoprazole or combination drugs, both in gastric and duodenal ulcers groups. Conclusion More expression improvement by endoscopy in patients receiving combination drugs with duodenal ulcers after re-taking aspirin.