CAJ | 학술논문

目的：探讨三磷酸腺苷(ATP)联合异丙肾上腺素在环肺静脉消融术中的应用价值。方法分别将30例与23例阵发性心房颤动(房颤)患者作为本研究的试验组与对照组,对照组单行环肺静脉消融术进行治疗,试验组在对照组基础上加用ATP与异丙肾上腺素的联合治疗。观察两组疗效。结果121根隔离肺静脉中有27根(22.3%)出现肺静脉电位恢复,这些病例均再次隔离后重新开始试验, ATP诱发肺静脉电位传导恢复发生在11例患者中,占总例数的36.7%；随访1~2年,试验组仅有5例(16.7%)患者出现中远期复发,而对照组共有7例(30.4%)患者出现远期复发,组间比较房颤的远期复发率试验组更低,差异有统计学意义(χ2=5.147,P<0.05)。结论ATP联合异丙肾上腺素在环肺静脉消融术中具有重要应用价值,值得心血管临床给予其更高程度的关注。
목적：탐토삼린산선감(ATP)연합이병신상선소재배폐정맥소융술중적응용개치。방법분별장30례여23례진발성심방전동(방전)환자작위본연구적시험조여대조조,대조조단행배폐정맥소융술진행치료,시험조재대조조기출상가용ATP여이병신상선소적연합치료。관찰량조료효。결과121근격리폐정맥중유27근(22.3%)출현폐정맥전위회복,저사병례균재차격리후중신개시시험, ATP유발폐정맥전위전도회복발생재11례환자중,점총례수적36.7%；수방1~2년,시험조부유5례(16.7%)환자출현중원기복발,이대조조공유7례(30.4%)환자출현원기복발,조간비교방전적원기복발솔시험조경저,차이유통계학의의(χ2=5.147,P<0.05)。결론ATP연합이병신상선소재배폐정맥소융술중구유중요응용개치,치득심혈관림상급여기경고정도적관주。
Objective To explore the application value of adenosine triphosphate (ATP) combined with isoprenaline in circumferential pulmonary vein ablation.Methods There were 30 cases and 23 cases of paroxysmal atrial fibrillation as experimental group and control group of this study. The control group received circumferential pulmonary vein ablation alone for treatment, while the experimental group received additional combination treatment by ATP and isoprenaline. Curative effects of the two groups were observed.Results Among 121 isolated pulmonary veins, there were 27 (22.3%) of them with pulmonary vein electrical recovery, and they all received isolation again for reexamination. There were 11 cases with recovered pulmonary vein electrical conduction induced by ATP, which accounted for 36.7%. After 1~2 years of follow-up, there were 5 cases (16.7%) of mid-long-term recurrence in the experimental group, and 7 cases (30.4%) of mid-long-term recurrence in the control group. The experimental group had much lower long-term recurrence rate of atrial fibrillation than the control group, and the difference between the two groups had statistical significance (χ2=5.147,P<0.05).Conclusion The combination of ATP and isoprenaline has important application value in circumferential pulmonary vein ablation, and it is worthy of high attention by cardiovascular clinic.