吉林医学
吉林醫學
길림의학
JILIN MEDICAL JOURANL
2015年
1期
13-14,15
,共3页
参芪扶正注射液%酒石酸美托洛尔%冠心病%慢性心力衰竭
參芪扶正註射液%酒石痠美託洛爾%冠心病%慢性心力衰竭
삼기부정주사액%주석산미탁락이%관심병%만성심력쇠갈
Shenqifuzheng injection%Metoprolol tartrate%Coronary heart disease%Chronic heart failure
目的：观察参芪扶正注射液联合酒石酸美托洛尔治疗冠心病慢性心力衰竭的疗效。方法：选择125例冠心病慢性心力衰竭患者。随机分为治疗组（63例）和对照组（62例）。对照组给予酒石酸美托洛尔、洋地黄、利尿剂、血管紧张素转换酶抑制剂、硝酸酯类、阿司匹林肠溶片、阿托伐他丁等常规治疗。治疗组在对照组基础上给予参芪扶正注射液250 ml静脉滴注，1次/d。疗程均为2周。比较治疗前后血浆脑钛肽（ BNP）水平、左室射血分数，每搏输出量及心排血量。观察治疗前后两组心功能的变化和组间差异。结果：治疗组对心功能改善总有效率（92.06%）明显高于对照组（77.42%），两组比较差异有统计学意义（P<0.05）。治疗组对左心室射血分数、每搏输出量、心排血量的改善及血浆BNP水平降低明显优于对照组，两组间比较差异有统计学意义（ P<0.05）。结论：参芪扶正注射液联合酒石酸美托洛尔治疗冠心病心力衰竭患者可改善临床症状和左心室收缩功能，降低血浆BNP水平，增强治疗作用，减少不良反应。
目的：觀察參芪扶正註射液聯閤酒石痠美託洛爾治療冠心病慢性心力衰竭的療效。方法：選擇125例冠心病慢性心力衰竭患者。隨機分為治療組（63例）和對照組（62例）。對照組給予酒石痠美託洛爾、洋地黃、利尿劑、血管緊張素轉換酶抑製劑、硝痠酯類、阿司匹林腸溶片、阿託伐他丁等常規治療。治療組在對照組基礎上給予參芪扶正註射液250 ml靜脈滴註，1次/d。療程均為2週。比較治療前後血漿腦鈦肽（ BNP）水平、左室射血分數，每搏輸齣量及心排血量。觀察治療前後兩組心功能的變化和組間差異。結果：治療組對心功能改善總有效率（92.06%）明顯高于對照組（77.42%），兩組比較差異有統計學意義（P<0.05）。治療組對左心室射血分數、每搏輸齣量、心排血量的改善及血漿BNP水平降低明顯優于對照組，兩組間比較差異有統計學意義（ P<0.05）。結論：參芪扶正註射液聯閤酒石痠美託洛爾治療冠心病心力衰竭患者可改善臨床癥狀和左心室收縮功能，降低血漿BNP水平，增彊治療作用，減少不良反應。
목적：관찰삼기부정주사액연합주석산미탁락이치료관심병만성심력쇠갈적료효。방법：선택125례관심병만성심력쇠갈환자。수궤분위치료조（63례）화대조조（62례）。대조조급여주석산미탁락이、양지황、이뇨제、혈관긴장소전환매억제제、초산지류、아사필림장용편、아탁벌타정등상규치료。치료조재대조조기출상급여삼기부정주사액250 ml정맥적주，1차/d。료정균위2주。비교치료전후혈장뇌태태（ BNP）수평、좌실사혈분수，매박수출량급심배혈량。관찰치료전후량조심공능적변화화조간차이。결과：치료조대심공능개선총유효솔（92.06%）명현고우대조조（77.42%），량조비교차이유통계학의의（P<0.05）。치료조대좌심실사혈분수、매박수출량、심배혈량적개선급혈장BNP수평강저명현우우대조조，량조간비교차이유통계학의의（ P<0.05）。결론：삼기부정주사액연합주석산미탁락이치료관심병심력쇠갈환자가개선림상증상화좌심실수축공능，강저혈장BNP수평，증강치료작용，감소불량반응。
Objective To observe the curative effect of Shenqifuzheng Injection Combined with metoprolol tartrate in the treatment of chronic congestive heart failure. Method 125 cases of coronary heart disease in patients with chronic failure stress were randomly divided into the treatment group(63 cases)and control group(62 cases). The control group was given metoprolol tartrate,digitalis,diuretics,an-giotensin converting enzyme inhibitors,nitrates,Aspirin Enteric-coated Tablets,atorvastatin D routine treatment. The treatment group based on in the control group was given Shenqifuzheng Injection 250 ml intravenous infusion of 1 times / d. Were treated for 2 weeks. Comparison of plasma BNP levels before and after treatment,the left ventricular ejection fraction,stroke volume and cardiac output. The two groups were observed before and after treatment the changes of cardiac function and the differences between groups. Results The treatment group im-proved on the heart function of total effective rate(92. 06%)was significantly higher than the control group(77. 42%),there was signifi-cant difference between two groups( P<0. 05 ). Improving the treatment group on left ventricular ejection fraction,stroke volume,cardiac output and plasma BNP level was significantly better than the control group,there was statistically significant difference between two groups ( P<0. 05). Conclusion Shenqi Fuzheng Injection Combined with metoprolol tartaric acid can improve the clinical symptoms of patients with coronary heart disease and heart failure and left ventricular systolic function,decrease plasma BNP level,enhance therapeutic effect, less side effect.
