CAJ | 학술논문

目的：探讨平衡针对家兔肩关节周围炎症治疗的作用及机制。方法家兔随机分为空白组、模型组和平衡针治疗组。采用持续机械劳损加冰敷造成肩周炎家兔模型，观察模型兔关节运动及患侧关节周围组织的病理变化并检测血浆和患侧局部组织中的转化生长因子－β1（ transfor－mating growth factor－β1，TGF－β1）和前列腺素－E2（ prostaglandin E－2，PGE－2）及羟脯氨酸（ hydroxypro－line，HYP）的含量。结果采用单因素ANOVA，统计结果用LSD进行分析，得出平衡针组家兔肱二头肌中转化生长因子－β1（transformating growth factor－β1，TGF－β1）及冈上肌中前列腺素－E2（prosta－glandin E－2，PGE－2）含量均较模型组明显降低，统计学差异极显著（P＜0．01）。结论平衡针通过降低模型兔肩关节周围组织中转化生长因子－β1（transformating growth factor－β1，TGF－β1）、前列腺素－E2（prostaglandin E－2，PGE－2）及炎性组织中羟脯氨酸（hydroxyproline，HYP）的含量，实现消除水肿、镇痛、抗炎作用，值得在临床推广和应用。
목적：탐토평형침대가토견관절주위염증치료적작용급궤제。방법가토수궤분위공백조、모형조화평형침치료조。채용지속궤계로손가빙부조성견주염가토모형，관찰모형토관절운동급환측관절주위조직적병리변화병검측혈장화환측국부조직중적전화생장인자－β1（ transfor－mating growth factor－β1，TGF－β1）화전렬선소－E2（ prostaglandin E－2，PGE－2）급간포안산（ hydroxypro－line，HYP）적함량。결과채용단인소ANOVA，통계결과용LSD진행분석，득출평형침조가토굉이두기중전화생장인자－β1（transformating growth factor－β1，TGF－β1）급강상기중전렬선소－E2（prosta－glandin E－2，PGE－2）함량균교모형조명현강저，통계학차이겁현저（P＜0．01）。결론평형침통과강저모형토견관절주위조직중전화생장인자－β1（transformating growth factor－β1，TGF－β1）、전렬선소－E2（prostaglandin E－2，PGE－2）급염성조직중간포안산（hydroxyproline，HYP）적함량，실현소제수종、진통、항염작용，치득재림상추엄화응용。
Objective Explore the effects and mechanism of rabbit scapulohumeral periarthritis ( SP ) model treated by balanced acupuncture .Methods Rabbits were divided into a blank group , a model group and a balanced acupuncture group .Establish the rabbit SP model by using persistent mechani-cal strain and ice compress .Observing the activities of rabbit sp model and the pathological change of ten -don of the tissue around the shoulder joint .Test the content of transforming growth factor-β1、prostaglandin E2 and hydroxyproline in plasma and local tissue .Results Use Single factor ANOVA to analyse the ex-perimental data,the results showed that compared with model group ,rabbit in the balanced acupuncture group presented both TGF-β1 in biceps and PGE-2 in supraspinatus muscle significantly lower , the differ-ence was statistically significant (P<0.01).Conclusion Balanced acupuncture by reducing the content of interleukin-1β, transforming growth factor-β1and prostaglandin E2 in the tissue around the shoulder joint of rabbit SP model and hydroxyproline in the inflammatory tissue to make the effects of eliminating edema , analgesia and anti-inflammatory.Balanced acupuncture by reducing the content of anti-pain factors and in-flammatory factors to improve the organization and adhesion of the local pathological tissue of rabbit SP model , then effectively treat the local and systemic syndromes .So it is valuable for widespread applying in clinic treatment .