CAJ | 학술논문

目的：寻找肺胀阳虚水泛证的关联性因素，探讨肺胀阳虚水泛证的病理机制。方法对符合诊断标准的临床收治肺胀阳虚水泛证、肺肾气虚证、痰热郁肺证患者分别采用双抗体夹心酶联免疫法检测尿水通道蛋白－2（aquaporin－2，AQP2）、放射免疫法检测血浆精氨酸加压素（argi－nine vasopressin，AVP）、酶联免疫吸附法检测血浆脑钠素（brain natriuretic peptide，BNP）、钠钾三磷酸腺苷酶（ Na+－K+－ATPase）水平，对阳虚水泛证、肺肾气虚证、痰热郁肺证三证之间相同项目指标分别采用秩和检验法比较相互之间的差异性，用相关分析法比较证型内指标之间的相关性。结果肺胀阳虚水泛证与痰热郁肺证的BNP水平有差异性（ P＜0．05），阳虚水泛证、肺肾气虚证、痰热郁肺证患者尿AQP2以及血浆钠钾ATP酶、AVP之间无统计学差异（ P＞0．05），三组钠钾ATP酶与BNP之间有正相关性（ P＜0．05），阳虚水泛证组及肺肾气虚证组的钠钾ATP酶与AVP之间有显著正相关性（P＜0．01）；BNP与AVP之间有显著正相关性（P＜0．01），阳虚水泛证AQP2与AVP之间有显著正相关性（ P＜0．01）。结论 BNP可能是肺胀阳虚水泛证的关键因素之一，需住院的肺胀阳虚水泛证、肺肾气虚证、痰热郁肺证患者均有阳虚因素的存在，尿AQP2以及血浆钠钾ATP酶、AVP可能是肺胀阳虚水泛证的内在因素之一。
목적：심조폐창양허수범증적관련성인소，탐토폐창양허수범증적병리궤제。방법대부합진단표준적림상수치폐창양허수범증、폐신기허증、담열욱폐증환자분별채용쌍항체협심매련면역법검측뇨수통도단백－2（aquaporin－2，AQP2）、방사면역법검측혈장정안산가압소（argi－nine vasopressin，AVP）、매련면역흡부법검측혈장뇌납소（brain natriuretic peptide，BNP）、납갑삼린산선감매（ Na+－K+－ATPase）수평，대양허수범증、폐신기허증、담열욱폐증삼증지간상동항목지표분별채용질화검험법비교상호지간적차이성，용상관분석법비교증형내지표지간적상관성。결과폐창양허수범증여담열욱폐증적BNP수평유차이성（ P＜0．05），양허수범증、폐신기허증、담열욱폐증환자뇨AQP2이급혈장납갑ATP매、AVP지간무통계학차이（ P＞0．05），삼조납갑ATP매여BNP지간유정상관성（ P＜0．05），양허수범증조급폐신기허증조적납갑ATP매여AVP지간유현저정상관성（P＜0．01）；BNP여AVP지간유현저정상관성（P＜0．01），양허수범증AQP2여AVP지간유현저정상관성（ P＜0．01）。결론 BNP가능시폐창양허수범증적관건인소지일，수주원적폐창양허수범증、폐신기허증、담열욱폐증환자균유양허인소적존재，뇨AQP2이급혈장납갑ATP매、AVP가능시폐창양허수범증적내재인소지일。
Objective Looking for lung distension water diffusion due to deficiency of Yang the correlation factors of the card , explore the pathogenesis of lung distension water diffusion due to deficiency of Yang the card.Methods To conform to the diagnostic standard of clinical treated lung distension water diffusion due to deficiency of Yang syndrome , lung and kidney deficiency syndrome , phlegm yu lung heat syndrome patients , respectively , with double antibody sandwich enzyme-linked immunoassay detection of u-rine aquaporin-2 ( AQP2 ) , ria method to detect the plasma arginine vasopressin ( AVP ) , enzyme-linked immunosorbent method to detect the plasma Brain natriuretic peptide (BNP), potassium sodium atpase en-zyme levels.To water diffusion due to deficiency of Yang syndrome , lung and kidney deficiency syndrome , phlegm heat yu lung between the three certificates same project indicators Rank and inspection were used respectively to compare the differences between each other .Compared with the method of correlation analy-sis of the correlation between card type in the index .Results Lung distension water diffusion due to defi-ciency of Yang syndrome and phlegm heat yu lung of BNP level was Statistically significant ( P<0.05 ) , water diffusion due to deficiency of Yang syndrome , lung and kidney deficiency syndrome , phlegm heat yu lung syndrome in patients with no statistical difference between of urinary AQP 2 and plasma potassium sodi-um atpase with AVP (P>0.05).Three groups of has a positive correlation between potassium sodium at-pase and BNP(P<0.05),Y water diffusion due to deficiency of Yang syndrome and lung and kidney defi- ciency syndrome group have significant positive correlation between potassium sodium atpase and AVP (P<0.01);significant positive correlation between the BNP and AVP (P<0.01), water diffusion due to deficiency of Yang card have significant positive correlation between AQP 2 and AVP (P<0.01).Conclu-sion The BNP may be lung distension water diffusion due to deficiency of Yang one of the key factors of the card.To be in hospital Lung distension of Water diffusion due to deficiency of yang syndrome , lung and kid-ney deficiency syndrome , phlegm heat yu lung syndrome patients have the existence of Yang deficiency fac -tor,Urinary AQP2 and plasma potassium sodium atpase , AVP may be lung distension water diffusion due to deficiency of Yang one of the internal factors of the card .